Table 2.

Plasma concentrations of amino acids and amines in nondialyzed patients with CKD stages 2–5 and hemodialyzed patients (micromoles per liter)

VariablesCKD2–5 (n=52)Hemodialysis (n=25)P Value
Total amino acid2558.3±441.72162.9±615.40.01a
Total essential amino acid989.8±237.9762.1±284.0<0.001a
Total nonessential amino acid1568.5±272.41400.8±379.80.06
Total branched chain amino acid405.4±138.1314.7±127.20.01a
Alanine320.9±102.8232.7±90.4<0.001a
Arginine91.0±29.968.0±29.6<0.001a
Asparagine40.9±10.040.5±14.60.58
Aspartate5.8±19.515.7±23.10.01a
Citrulline49.9±24.267.5±26.10.01a
Glutamine526.6±70.3473.2±117.80.04a
Glutamate84.9±83.458.3±49.00.09
Glycine187.6±62.2166.8±54.00.27
Histidine76.4±14.967.8±25.60.03a
Isoleucine75.9±28.661.5±25.40.03a
Leucine114.0±50.087.3±47.60.02a
Lysine189.6±45.1150.3±62.90.001a
Methionine37.5±11.426.8±12.0<0.001a
Ornithine60.9±22.956.1±19.30.39
Phenylalanine67.0±15.859.2±18.00.06
Proline228.9±70.5279.7±108.70.04a
Serine82.0±19.365.9±27.60.003a
Threonine100.6±29.975.8±36.50.01a
Tryptophan48.4±14.424.0±14.1<0.001a
Tyrosine65.0±22.743.5±17.8<0.001a
Valine215.4±69.0165.9±62.10.003a
Asymmetric dimethylarginine0.81±0.41.79±0.6<0.001a
Symmetric dimethylarginine1.17±2.40.64±0.40.03a
Hydroxykynurenine2.07±1.25.50±1.8<0.001a
  • All values are mean ± SD.

  • a P<0.05.