Table 4.

Comparison of clinical, laboratory, and pathologic findings between patients with late-onset uveitis TINU syndrome and DATIN

CharacteristicPatients with 
Late-Onset Uveitis TINU (n=18)Patients with 
DATIN (n=61)P Value
Age (yr)46.2±10.947.0±12.70.82
Male/female sex (% male)1/17 (6)16/45 (26)0.06
Thyroid disease6 (33)7 (12)0.03
Hemoglobin (g/L)90.0 (76.0–137.0)94.0 (72.0–150.0)0.28
Erythrocyte sedimentation rate (mm/h)88.5 (45.0–140.0)60.0 (2.0–140.0)0.02
C-reactive protein (mg/L)18.5 (3.9–74.3)7.2 (1.0–136.0)0.01
Eosinophilia0 (0)5 (8)0.21
mCRP-Ab (↑%)a21.8 (6.4–44.3); 6710.9 (0.9–29.1); 12<0.001
Serum creatinine at biopsy (μmol/L)257.5 (160.0–825.0)239.0 (98.0–988.0)0.56
Estimated GFR at biopsy (ml/min per 1.73 m2)17.6 (5.8–36.6)24.3 (3.4–82.8)0.35
N-acetyl-β-d-glucosaminidase (U/L)32.0 (10.0–57.0)21.0 (4.0–117.0)0.34
α1-Microglobulin (mg/L)213.0 (36.2–362.0)184.0 (2.4–402.0)0.32
Urine osmotic pressure (mOsm/kg)399.5 (292.0–596.0)383.0 (222.0–655.0)0.63
Renal glycosuria (↑%)17 (94)51 (84)0.24
Leukocyturia (↑%)9 (50)28 (46)0.76
Eosinophiluria0 (0)0 (0)1.00
Histologic activity index≥414 (78)47 (77)0.95
Histologic chronicity index≤214 (78)48 (79)0.93
Eosinophil on biopsy (×200)2.6 (0.4–31.8)1.9 (0.0–33.8)0.08
  • Data are presented as mean ± SD, n (%), or median (interquartile range) unless otherwise specified. mCRP-Ab, autoantibody against modified C-reactive protein; TINU, tubulointerstitial nephritis and uveitis; DATIN, drug-induced acute tubulointerstitial nephritis.

  • a Percentage of positive control.