Table 5.

Odds ratio of acidosis by net endogenous acid production within age categories

Net Endogenous Acid ProductionOdds Ratio (95% Confidence Interval)
Model 1Model 2Model 3
Age 20–39 yr (n=3299)
 Continuousa1.02 (0.92 to 1.13)1.06 (0.96 to 1.19)1.03 (0.92 to 1.15)
 <39.3 mEq/dReferenceReferenceReference
 39.3–52.9 mEq/d0.97 (0.63 to 1.50)1.02 (0.66 to 1.58)0.96 (0.61 to 1.52)
 53.0–69.9 mEq/d1.15 (0.77 to 1.72)1.28 (0.87 to 1.87)1.14 (0.80 to 1.62)
 ≥70.0 mEq/d1.16 (0.83 to 1.61)1.31 (0.96 to 1.79)1.04 (0.84 to 1.56)
 P for trend0.250.080.28
Age 40–59 yr (n=3139)
 Continuousa1.27 (1.10 to 1.48)b1.31 (1.13 to 1.52)b1.22 (1.03 to 1.45)b
 <39.3 mEq/dReferenceReferenceReference
 39.3–52.9 mEq/d1.19 (0.81 to 1.73)1.25 (0.86 to 1.80)1.27 (0.88 to 1.82)
 53.0–69.9 mEq/d1.39 (0.98 to 1.95)1.42 (1.01 to 2.01)b1.38 (0.94 to 2.04)
 ≥70.0 mEq/d1.78 (1.07 to 2.94)b1.91 (1.18 to 3.08)b1.65 (0.98 to 2.78)
 P for trend0.020.010.06
Age≥60 yr (n=3343)
 Continuousa1.13 (0.96 to 1.34)1.12 (0.94 to 1.34)1.11 (0.93 to 1.33)
 <39.3 mEq/dReferenceReferenceReference
 39.3–52.9 mEq/d1.08 (0.71 to 1.63)1.06 (0.69 to 1.63)1.09 (0.69 to 1.72)
 53.0–69.9 mEq/d1.27 (0.84 to 1.91)1.24 (0.81 to 1.88)1.22 (0.81 to 1.84)
 ≥70.0 mEq/d1.47 (0.97 to 2.25)1.46 (0.93 to 2.28)1.44 (0.91 to 2.29)
 P for trend0.050.080.09
  • Model 1: unadjusted. Model 2: adjusted for age, sex, and race/ethnicity. Model 3: model 2 adjusted for body mass index, poverty, education, smoking status, diuretic use, diagnosis of diabetes mellitus, hypertension, cardiovascular disease, estimated GFR, log-transformed urine albumin–creatinine ratio, serum albumin, and log-transformed C-reactive protein. P for interaction by age=0.02.

  • a Per SD higher net endogenous acid production (SD=26.4 mEq/d).

  • b P<0.05.