Table 2.

Association of net endogenous acid production with serum bicarbonate in 9781 participants of the National Health and Nutrition Examination Survey 1999–2004

Net Endogenous Acid ProductionCoefficient (95% Confidence Interval)
Model 1Model 2Model 3
Continuousa−0.22 (−0.28 to −0.16)b−0.20 (−0.26 to −0.14)b−0.15 (−0.20 to −0.10)b
<39.3 mEq/dReferenceReferenceReference
39.3–52.9 mEq/d−0.12 (−0.27 to −0.04)−0.13 (−0.28 to −0.01)−0.11 (−0.26 to −0.03)b
53.0–69.9 mEq/d−0.35 (−0.55 to −0.16)b−0.33 (−0.52 to −0.14)b−0.24 (−0.42 to −0.07)b
≥70.0 mEq/d−0.59 (−0.76 to −0.43)b−0.53 (−0.70 to −0.36)b−0.40 (−0.55 to −0.26)b
P for trend<0.001<0.001<0.001
  • Model 1: unadjusted. Model 2: adjusted for age, sex, and race/ethnicity. Model 3: model 2 adjusted for body mass index, poverty, education, smoking status, diuretic use, diagnosis of diabetes mellitus, hypertension, cardiovascular disease, estimated GFR, log-transformed urine albumin–creatinine ratio, serum albumin, and log-transformed C-reactive protein.

  • a Per SD higher net endogenous acid production (SD=26.4 mEq/d).

  • b P<0.05.