Table 5.

Plasma ratios of amino acids and amines in nondialyzed and dialyzed CKD patients

VariablesCKD2–3CKD4–5HemodialysisP Value
EAA/NEAA0.68±0.160.60±0.120.55±0.14<0.01a
Orn/Arg0.62±0.230.77±0.300.93±0.460.01a
Arg/Cit2.83±1.311.60±0.531.09±0.44<0.001a
Cit/Orn0.71±0.270.96±0.331.24±0.41<0.001a
Pro/Orn4.14±1.143.96±1.485.26±2.160.01a
Tyr/Phe1.05±0.230.90±0.230.73±0.17<0.001a
Val/Gly1.29±0.681.19±0.461.11±0.670.58
Ser/Gly0.47±0.130.45±0.110.40±0.120.12
Ala/BCAA0.78±0.300.91±0.290.80±0.300.25
ADMA/SDMA0.73±0.461.36±1.012.95±1.65<0.001a
Arg/ADMA193.6±115.7115.8±73.141.3±20.5<0.001a
OH-Kyn/Trp0.023±0.0200.082±0.0720.262±0.094<0.001a
  • All values are mean ± SD. EAA, sum of essential amino acids; NEAA, sum of nonessential amino acids; Orn, ornithine; Arg, arginine; Cit, citrulline; Pro, proline; Tyr, tyrosine; Phe, phenylalanine; Val, valine; Gly, glycine; Ser, serine; Ala, alanine; BCAA, branched chain amino acid; ADMA, asymmetric dimethylarginine; SDMA, symmetric dimethylarginine; OH-Kyn, hydroxykynurenine; Trp, tryptophan.

  • a P<0.05.