Characteristics of cohort of post–cardiac surgery patients enrolled in study
| Characteristic | AKIN Stage 1 or 2 and Survived | AKIN Stage 3 or Death | P Value |
|---|---|---|---|
| Patients (n) | 178 | 26 | |
| Age (yr)a,b | 68 (59.0–76.0) | 65.5 (58.0–79.0) | 0.97 |
| Women, % (n) | 32.6 (58) | 38.5 (10) | 0.71 |
| White, % (n) | 70.2 (125) | 69.2 (18) | 0.9 |
| Surgical variablesa | |||
| CABG, % (n) | 46.6 (83) | 34.6 (9) | 0.35 |
| Valve replacement, % (n) | 28.7 (51) | 26.9 (7) | 0.96 |
| CABG + valve, % (n) | 16.9 (30) | 23.1 (6) | 0.62 |
| Other, % (n) | 7.9 (14) | 15.4 (4) | 0.37 |
| Bypass, % (n) | 86.0 (153) | 88.5 (23) | 0.97 |
| Bypass time (min)b | 141.0 (83.0–192.0) | 159.5 (62.0–203.0) | 0.66 |
| Collection time (hr postop)b | 21.8 (19.2–43.0) | 21.6 (19.2–33.6) | 0.69 |
| Serum creatinine (mg/dl) | |||
| Preoperativeb | 1.1 (0.9–1.3) | 1.3 (1.0–1.8) | 0.02 |
| At collectionb | 1.6 (1.3–1.9) | 1.9 (1.6–3.1) | <0.001 |
| Increase at collection (%)b | 41 (30–56) | 64 (35–80) | 0.003 |
| Outcomes | |||
| Time to maximum creatinine (d)b,c | 2.0 (1.0–3.0) | 5.0 (3.75–8.0) | <0.001 |
| Time to discharge or death (d)b,c | 7.0 (6.0–10.0) | 14.0 (9.75–24.75) | <0.001 |
| AKIN stage 3, % (n) | 0 (0) | 84.6 (22) | <0.001 |
| AKIN stage 3 or death, % (n) | 0 (0) | 100 (26) | <0.001 |
| Death, % (n) | 0 (0) | 34.6 (9) | <0.001 |
| Renal replacement therapy, % (n) | 0 (0) | 50.0 (13) | <0.001 |
Statistical significance was determined by the chi-squared test for categorical variables and the Mann-Whitney U test for continuous variables. AKIN, Acute Kidney Injury Network; CABG, coronary artery bypass grafting.
↵a Type of surgery is reported as CABG only, valve replacement only, CABG + valve replacement, and other procedures.
↵b Continuous variables are reported as median (interquartile range).
↵c Days are reported as the number of days after surgery.