Table 1.

Key demographic and clinical data at time of kidney biopsy

CharacteristicsDN AloneDN Plus NDRDNDRD Alone
Participants (n)227164220
Age (yr)59 (49–65)63 (55–72)a63 (54–70)b
Male sex129 (56.8)100 (61.0)142 (64.6)
Race
 Unknown108 (47.6)57 (34.8)a104 (47.3)c
 White62 (27.3)63 (38.4)a70 (31.8)
 African American39 (17.2)33 (20.1)29 (13.2)
 Hispanic12 (5.3)7 (4.3)8 (3.6)
 Asian4 (1.8)4 (2.4)7 (3.2)
 Other2 (0.9)0 (0.0)2 (0.9)
DM type 19 (4.0)5 (3.1)2 (0.9)b
Duration of DM (yr)13 (8–17)10 (7–18)5 (3–10)b,c
Serum creatinine (mg/dl)2.3 (1.6–3.8)3.1 (1.7–5.2)a2.3 (1.5–4.4)c
eGFR (ml/min per 1.73 m2)31.3 (17.5–55.2)21.4 (12.5–46.6)a32.5 (14.3–60.0)c
Proteinuria (g/d)5.0 (2.8–8.8)5.0 (2.0–8.0)2.9 (1.4–7.1)b,c
  • Of 620 patients with diabetes who underwent biopsy, 611 had adequate tissue for diagnosis. Categorical variables are expressed as n (%); continuous variables are expressed as median (interquartile range). DN, diabetic nephropathy; NDRD, nondiabetic renal disease; DM, diabetes mellitus; eGFR, estimated GFR.

  • a P<0.05 for comparison of DN plus NDRD versus DN alone subgroups.

  • b P<0.05 for comparison of NDRD alone versus DN alone subgroups.

  • c P<0.05 for comparison of NDRD alone versus DN plus NDRD subgroups.