Table 1.

Clinical characteristics at baseline of 273 patients with ANCA-associated vasculitis: Differences between patients without and with renal involvement

CharacteristicPatients without Renal InvolvementPatients with Renal InvolvementP Value
Number61212
Age (yr)52±1458±160.01a
Sex321260.94
Diagnosis
 Granulomatosis with polyangiitis55132<0.001a
 Microscopic polyangiitis6520.01a
 Renal limited vasculitis028
Comorbidity
 Hypertension140.90
 Diabetes mellitus1150.11
 Cardiovascular disease6200.34
 Autoimmune diseasesb190.34
 Malignancy4150.89
Ear, nose, and throat52124<0.001a
Pulmonary2640<0.001a
Birmingham Vasculitis Activity Score13 (7–27)23 (7–48)<0.001a
Creatinine (mg/dl)0.94±0.203.63±3.42<0.001a
C-reactive protein7.6±8.310.8±9.00.001a
Proteinuria (g/24 h)0.091.7<0.001a
Renal replacement therapy049c
Plasmapheresis048
  • Data are presented as the number, mean ± SD, or median (range).

  • a Statistically significant.

  • b Concomitant autoimmune diseases included Crohn’s disease (n=1) in patients without renal involvement, and Sjögren’s syndrome (n=1), sarcoidosis (n=1), psoriasis (n=1), hypothyroidism (n=4), and hyperthyroidism (n=2) in patients with renal involvement.

  • c There were 48 PR3-ANCA–positive and MPO-ANCA–positive patients, and 1 PR3-ANCA–negative and MPO-ANCA–negative patient.