Table 2.

Summary of NDRD, with and without DN, found on biopsies of patients with diabetes

Types of NDRD (n)NDRD Alone (n=220)DN Plus NDRD (n=164)P Valuea
Acute tubular necrosis (109)38 (17.3)71 (43.3)<0.001
FSGS (69)48 (21.8)21 (12.8)0.02
 Primary FSGS (6)6 (2.7)0 (0.0)0.03
 Secondary FSGS (63)b
  HTN related19 (8.6)10 (6.1)0.35
  HTN plus obesity related16 (7.3)10 (6.1)0.65
  Obesity related4 (1.8)1 (0.6)0.30
  Otherc3 (1.4)0 (0.0)0.13
Hypertensive nephrosclerosis (70)b39 (17.7)31 (18.9)0.77
IgA nephropathy (35)23 (10.5)12 (7.3)0.29
Membranous GN (23)18 (8.2)5 (3.0)0.04
Pauci-immune crescentic GN (19)15 (6.8)4 (2.4)0.05
Acute interstitial nephritis (18)11 (5.0)7 (4.3)0.73
Amyloidosis (10)10 (4.5)0 (0)0.01
Myeloma cast nephropathy (10)8 (3.6)2 (1.2)0.14
Acute postinfectious GN (6)3 (1.4)3 (1.8)0.72
Atheroembolic disease (5)2 (0.9)3 (1.8)0.43
Others (10)5 (2.3)5 (3.0)0.64
  • Values are expressed as n (%). NDRD, nondiabetic renal disease; DN, diabetic nephropathy; HTN, hypertension.

  • a P value is from a two-sample test of proportions

  • b Thirteen cases of secondary FSGS in the NDRD alone subgroup and 16 cases of secondary FSGS in the DN plus NDRD subgroup also showed features of hypertensive nephrosclerosis.

  • c Includes increased muscle mass (n=1), solitary kidney (n=1), and familial FSGS (n=1)