Table 3.

Percent of patients with systemic lupus erythematosus and progressive lupus nephritis versus percentage of matched controls without lupus nephritis who had both an absolute and a percentage rate of increase in anti–double-stranded DNA antibody above specific thresholds

DsDNAPatients (%)Controls (%)Odds Ratio (95% Confidence Interval) P Value (Fisher Exact Test)
Change in IU/ml per yr
 >0 IU/ml75 (15/20)22 (4/18)11 (2.3 to 47)0.003
 >0.5 IU/ml75 (15/20)0 (0/18)76 (8 to 751)a<0.001
 >1 IU/ml70 (14/20)0 (0/18)57 (6 to 542)a<0.001
Change in % per yr
 >0%80 (16/20)22 (4/18)14 (2.9 to 67)<0.001
 >10%75 (15/20)11 (2/18)24 (4 to 143)<0.001
 >50%70 (14/20)0 (0/18)60 (6.3 to 569)a<0.001
  • Only 20 patients and 18 controls had multiple serum samples for evaluation of change in anti–double-stranded DNA antibody levels over time. Percentages are accompanied by n/n in parentheses. dsDNA, double-stranded DNA.

  • a Estimated because of actual infinite value.