Table 4.

Correlations between the 24-hour urinary excretions of albumin and the various damage markers in participants with progressive albuminuria (n=183) and matched controls (n=366)

MarkerAlbuminIgG TotalIgG4KIM-1CysCB2MGNAGNGALMCP-1H-FABP
Participants with progressive albuminuria
 Albumin0.51 (<0.001)0.42 (<0.001)0.28 (<0.001)0.45 (<0.001)0.46 (<0.001)0.24 (0.002)0.38 (<0.001)−0.05 (0.52)0.50 (<0.001)
 IgG total0.42 (<0.001)0.26 (<0.001)0.40 (<0.001)0.47 (<0.001)−0.04 (0.62)0.35 (<0.001)0.08 (0.31)0.36 (<0.001)
 IgG40.26 (0.001)0.40 (<0.001)0.45 (<0.001)0.18 (0.02)0.28 (<0.001)0.01 (0.87)0.36 (<0.001)
 KIM-10.47 (<0.001)0.41 (<0.001)0.08 (0.27)0.19 (0.01)0.34 (<0.001)0.25 (0.001)
 CysC0.69 (<0.001)0.12 (<0.001)0.35 (<0.001)0.13 (0.08)0.51 (<0.001)
 B2MG0.14 (0.07)0.51 (<0.001)−0.08 (0.27)0.60 (<0.001)
 NAG0.02 (0.76)0.02 (0.80)0.30 (<0.001)
 NGAL−0.14 (0.06)0.35 (<0.001)
 MCP-1−0.08 (0.31)
Matched controls
 Albumin0.36 (<0.001)0.35 (<0.001)0.30 (<0.001)0.45 (<0.001)0.48 (<0.001)0.14 (0.01)0.26 (<0.001)0.07 (0.22)0.33 (<0.001)
 IgG total0.39 (<0.001)0.33 (<0.001)0.33 (<0.001)0.47 (<0.001)0.22 (<0.001)0.44 (<0.001)0.07 (0.18)0.31 (<0.001)
 IgG-40.28 (<0.001)0.37 (<0.001)0.42 (<0.001)−0.007 (0.89)0.28 (<0.001)0.20 (<0.001)0.31 (<0.001)
 KIM-10.39 (<0.001)0.49 (<0.001)0.11 (0.04)0.20 (0.01)0.34 (<0.001)0.33 (0.001)
 CysC0.74 (<0.001)0.18 (0.001)0.24 (<0.001)0.18 (0.001)0.59 (<0.001)
 B2MG0.19 (<0.001)0.45 (<0.001)0.15 (0.003)0.54 (<0.001)
 NAG0.31 (<0.001)0.01 (0.83)0.26 (<0.001)
 NGAL0.10 (0.05)0.18 (0.001)
 MCP-10.26 (<0.001)
  • Data are presented as Spearman’s ρ and the corresponding P value. KIM-1, kidney injury molecule-1; CysC, cystatin C; β2MG, β2-microglobulin; NAG, N-acetyl-β-D-glucosaminidase; NGAL, neutrophil gelatinase-associated lipocalin; MCP-1 monocyte chemoattractant protein-1; H-FABP, heart-type fatty acid-binding protein.