Table 2.

Baseline urinary excretions of renal damage markers at baseline of participants with progressive albuminuria (progressors, n=183), their matched controls (n=366, matched for baseline albuminuria, age and sex), as well as healthy controls

MarkerHealthy ControlsProgressorsMatched ControlsP Value
Albumin (mg/24 h)7.8 (6.4–10.4)58 (33–106)52 (31–88)0.24
Glomerular
 IgG (mg/24 h)0.2 (0.2–0.3)1.29 (0.93–2.18)1.12 (0.70–2.04)<0.01
 IgG4 (µg/24 h)158 (0–239)174 (0–290)0.14
Proximal tubular
 KIM-1 (µg/24 h)0.8 (0.4–1.2)3.9 (1.9–7.0)7.4 (3.2–15.0)<0.001
 CysC (µg/24 h)0.01 (0.005–0.03)0.02 (0.005–0.04)0.24
 β2MG (µg/24 h)79.4 (49.1–121.3)103 (39–395)169 (58–641)<0.01
 NAG (U/24 h)0.4 (0.3–2.4)0.01 (0.00–0.26)0.69 (0.00–1.86)<0.001
Inflammatory
 NGAL (µg/24 h)5.5 (2.7–9.6)6.7 (3.9–11.4)0.01
 MCP-1 (ng/24 h)273 (178–400)467 (261–825)741 (522–911)<0.001
Distal tubular
 H-FABP (µg/24 h)1.4 (1.0–2.2)3.4 (0.8–7.2)2.0 (5.9–7.3)0.08
  • KIM-1, kidney injury molecule-1; CysC, cystatin C; β2MG, β2-microglobulin; NAG, N-acetyl-β-D-glucosaminidase; NGAL, neutrophil gelatinase-associated lipocalin; MCP-1 monocyte chemoattractant protein-1; H-FABP, heart-type fatty acid-binding protein.