Table 3.

Description of potential adverse drug events and adverse drug events

EventIncidence n (%)
pADE (n=93)
 Contraindicated use for >24 hours26 (28)
 No dose adjustment for >24 hours15 (16)
 No interval adjustment for >24 hours44 (47)
 Ineffective at low creatinine clearance2 (2)
 No drug level monitoring5 (5)
 No creatinine monitoring3 (3)
 Other6 (6)
Laboratory-only ADE (n=21)
 Hyperkalemia2 (10)
 Supratherapeutic drug levels19 (90)
  Vancomycin18
  Tobramycin1
ADE (n=52)
 Hypotension11 (21)
 QT prolongation2 (4)
 Cognitive changes/somnolence4 (8)
 Delirium1 (2)
 Extrapyramidal symptoms1 (2)
 Oversedation6 (11)
 Rash1 (2)
 Major bleed1 (2)
 Minor bleed5 (10)
 Worsening AKI24 (46)
 Crystalurea1 (2)
 Respiratory depression2 (4)
 Hemodialysis3 (6)
 Colitis1 (2)
 Death1 (2)
  • Subcategory numbers and percentages may exceed the total n or 100%, because one event could be composed of multiple adverse drug events (ADEs) or potential ADEs (pADEs). Supplemental Table 2 has definitions of each ADE and laboratory-only ADE.