Table 3.

The association between fibroblast growth factor-23 and major cardiovascular events in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort: separate models for different mineral metabolism variables and indices of subclinical cardiovascular patholog

Tertile 1 (FGF23≤36 pg/ml)Tertiles 2 and 3 (FGF23>36 pg/ml)
Model B (age, sex, and estimated GFR)Referent1.92 (1.19–3.09)a
Mineral metabolism variables
 Model B + serum parathyroid hormoneReferent1.92 (1.19–3.10)a
 Model B + serum vitamin DReferent1.99 (1.23–3.21)a
 Model B + serum calciumReferent1.87 (1.15–3.02)b
 Model B + serum phosphateReferent1.77 (1.09–2.86)b
Indices of subclinical cardiovascular pathology
 Model B + left ventricular massReferent1.84 (1.14–2.98)b
 Model B + left ventricular ejection fractionReferent1.92 (1.19–3.09)a
 Model B + endothelium-dependent vasodilationReferent1.88 (1.17–3.03)a
 Model B + endothelium-independent vasodilationReferent1.88 (1.17–3.03)a
 Model B + flow-mediated dilatationReferent1.92 (1.19–3.10)a
 Model B + pulse-wave reflection indexReferent1.94 (1.20–3.12)a
 Model B + intima media thicknessReferent1.92 (1.19–3.10)a
  • Data are odds ratios for tertiles 2 and 3 versus tertile 1 of FGF23. Tertile data are given as odds ratio (95% confidence interval). FGF23, fibroblast growth factor-23.

  • a P<0.01.

  • b P<0.05.