Table 2.

The association between serum fibroblast growth factor-23 and major cardiovascular events in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort

No. of events/no. at riskModel AModel BModel CModel D
Multicategory models
 Tertile 1 (<36 pg/ml)24/335ReferentReferentReferentReferent
 Tertile 2 (36–50 pg/ml)45/3342.05 (1.22–3.47)a2.05 (1.22–3.46)a1.95 (1.15–3.32)b2.00 (1.18–3.39)b
 Tertile 3 (≥50 pg/ml)43/3341.83 (1.08–3.11)b1.79 (1.05–3.06)b1.70 (0.98–2.94)c1.68 (0.97–2.90)c
Threshold models
 Tertile 1 (<36 pg/ml)24/335ReferentReferentReferentReferent
 Tertile 2 and 3 (≥36 pg/ml)88/6681.94 (1.21–3.12)a1.92 (1.19–3.09)a1.83 (1.12–2.98)b1.84 (1.14–2.98)b
  • Model A is adjusted for age and sex. Model B is adjusted for covariates in model A and estimated GFR. Model C is adjusted for covariates in model B and variables reflecting mineral metabolism (parathyroid hormone, vitamin D, calcium, and phosphate). Model D is adjusted for covariates in model B and markers of cardiovascular pathology (left ventricular mass, left ventricular ejection fraction, endothelial-dependent and -independent vasodilation, flow-mediated dilation, arterial stiffness, and intima media thickness). Model data are given as odds ratio (95% confidence interval).

  • a P<0.01.

  • b P<0.05.

  • c P=0.06.