No. of events/no. at risk | Model A | Model B | Model C | Model D | |
---|---|---|---|---|---|

Multicategory models | |||||

Tertile 1 (<36 pg/ml) | 24/335 | Referent | Referent | Referent | Referent |

Tertile 2 (36–50 pg/ml) | 45/334 | 2.05 (1.22–3.47)^{a} | 2.05 (1.22–3.46)^{a} | 1.95 (1.15–3.32)^{b} | 2.00 (1.18–3.39)^{b} |

Tertile 3 (≥50 pg/ml) | 43/334 | 1.83 (1.08–3.11)^{b} | 1.79 (1.05–3.06)^{b} | 1.70 (0.98–2.94)^{c} | 1.68 (0.97–2.90)^{c} |

Threshold models | |||||

Tertile 1 (<36 pg/ml) | 24/335 | Referent | Referent | Referent | Referent |

Tertile 2 and 3 (≥36 pg/ml) | 88/668 | 1.94 (1.21–3.12)^{a} | 1.92 (1.19–3.09)^{a} | 1.83 (1.12–2.98)^{b} | 1.84 (1.14–2.98)^{b} |

Model A is adjusted for age and sex. Model B is adjusted for covariates in model A and estimated GFR. Model C is adjusted for covariates in model B and variables reflecting mineral metabolism (parathyroid hormone, vitamin D, calcium, and phosphate). Model D is adjusted for covariates in model B and markers of cardiovascular pathology (left ventricular mass, left ventricular ejection fraction, endothelial-dependent and -independent vasodilation, flow-mediated dilation, arterial stiffness, and intima media thickness). Model data are given as odds ratio (95% confidence interval).

↵a

*P*<0.01.↵b

*P*<0.05.↵c

*P*=0.06.