Table 3.

Baseline and final biomarkers

Serum Biochemical MeasuresNo GH TherapyGH Therapy
InitialFinalInitialFinal
High bone turnover on initial bone biopsy
 Patients (n)11986
 Corrected calcium (mg/dl)a9.4±0.99.6±0.59.9±1.19.3±0.8
 Phosphorus (mg/dl)5.8±0.95.7±0.85.2±0.97.0±2.5
 Alkaline phosphatase (IU/L)a436 (374, 703)371 (198, 508)b278 (253, 328)370 (250, 580)b
 PTH (pg/ml)a728 (411, 1078)335 (152, 867)533 (491, 669)579 (578, 767)
 IGF-1 (ng/ml)356 (133, 435)235 (182, 405)254 (235, 380)319 (182, 329)
Low/normal bone turnover on initial bone biopsy
 Patients (n)7577
 Corrected calcium (mg/dl)a9.6±0.79.4±0.510.0±0.79.1±1.1
 Phosphorus (mg/dl)6.5±1.87.4±2.25.1±1.86.5±1.2b
 Alkaline phosphatase (IU/L)a306 (185, 434)332 (170, 465)b185 (139, 303)285 (240, 392)b
 PTH (pg/ml)a136 (62, 332)755 (110, 803)119 (89, 125)775 (310, 1361)b
 IGF-1 (ng/ml)229 (100, 462)313 (104, 522)191 (159, 320)490 (292, 554)b
  • Normally distributed values are displayed as mean ± SD; skewed data are displayed as median (interquartile range).

  • a P<0.05 between patients with high turnover and patients with low-normal turnover at baseline.

  • b P<0.05 from baseline.