Table 1.

Biomarker performance from multicenter studies at a variety of clinical time points in cardiac surgery and critical illness

Cardiac SurgeryCritical Illness/Sepsis
Preop AKI Risk AssessmentEarly Postop Diagnosis of AKIAKI ProgressionEarly Diagnosis of AKIClassification of AKI (Transient Versus Intrinsic AKI)Prediction of Dialysis
U NGALN/A++++
B NGAL++?
U CysCN/A+++
U IL-18N/A+++++
U KIM-1aN/A++
U protein/albumin+++???
  • Preop, preoperative; postop, postoperative; NGAL, neutrophil gelatinase-associated lipocalin; N/A, not applicable (biomarkers of tubular injury have no role in preoperative risk screening); +, data published displays the ability to detect this aspect of AKI; −, data published does not display the ability to detect this aspect of AKI; ?, no large multicenter data published on this biomarker/aspect of AKI; B, blood CysC, cystatin C; KIM-1, kidney injury molecule-1; U, urine.

  • aKIM-1 data from the TRIBE-AKI study are under review.