Table 1.

Biomarker performance from multicenter studies at a variety of clinical time points in cardiac surgery and critical illness

	Cardiac Surgery			Critical Illness/Sepsis
	Preop AKI Risk Assessment	Early Postop Diagnosis of AKI	AKI Progression	Early Diagnosis of AKI	Classification of AKI (Transient Versus Intrinsic AKI)	Prediction of Dialysis
U NGAL	N/A	+	−	+	+	+
B NGAL	−	+	+	−	?	−
U CysC	N/A	−	−	+	+	+
U IL-18	N/A	+	+	+	+	+
U KIM-1^a	N/A	+	−	+	−	−
U protein/albumin	+	+	+	?	?	?

Preop, preoperative; postop, postoperative; NGAL, neutrophil gelatinase-associated lipocalin; N/A, not applicable (biomarkers of tubular injury have no role in preoperative risk screening); +, data published displays the ability to detect this aspect of AKI; −, data published does not display the ability to detect this aspect of AKI; ?, no large multicenter data published on this biomarker/aspect of AKI; B, blood CysC, cystatin C; KIM-1, kidney injury molecule-1; U, urine.
↵^aKIM-1 data from the TRIBE-AKI study are under review.