Table 1.

Baseline characteristics and study assignment of patients by tertile of SBV

TotalTertile of SBVP for Trenda
123
Patients (n)908302303303
SBV (mmHg)13.6 (7.5)6.4 (1.9)12.2 (1.8)22.1 (6.1)
Study assignments, n (%)
 Ramipril357 (39)113 (31)106 (30)138 (39)0.04
 Amlodipine181 (20)84 (46)58 (32)39 (22)<0.001
 Metoprolol370 (41)105 (28)139 (38)126 (34)0.09
 Low BP goal462 (51)149 (32)151 (33)162 (35)0.31
 Usual BP goal446 (49)153 (34)152 (34)141 (32)0.31
Covariates, mean (SD)
 Age (yr)55 (11)55 (11)56 (10)54 (11)0.33
 Baseline systolic BP (mmHg)150 (24)145 (21)151 (25)153 (24)<0.001
 Baseline mGFR (ml/min per 1.73m2)47 (14)48 (14)47 (13)45 (14)0.02
 Baseline body mass index (kg/m2)30.6 (6.6)31.2 (6.6)30.8 (6.5)29.6 (6.8)0.002
 Baseline urine protein (g/d)0.51 (0.91)0.49 (0.85)0.49 (0.89)0.55 (0.99)0.33
 Baseline urine protein/creatinine0.31 (0.51)0.28 (0.47)0.29 (0.49)0.35 (0.55)0.12
 Baseline urine Na (g/d)3.69 (1.98)3.68 (2.01)3.75 (1.89)3.62 (2.04)0.86
 Mean systolic BP mo 3–12 (mmHg)136 (14)131 (12)136 (13)142 (15)<0.001
 12-mo serum albumin (g/dl)4.13 (0.34)4.16 (0.37)4.13 (0.32)4.11 (0.34)0.34
 12-mo mGFR (ml/min per 1.73m2)45 (17)47 (18)46 (17)43 (17)0.01
 12-mo urine protein (g/d)0.54 (1.16)0.45 (0.86)0.52 (1.08)0.66 (1.49)0.07
 12-mo urine protein/creatinine0.34 (0.68)0.29 (0.55)0.32 (0.64)0.42 (0.83)0.21
 Compliance (%)71 (29)78 (26)71 (30)66 (30)0.001
Men, n (%)562 (62)178 (32)198 (35)186 (33)0.54
Current smoker, n (%)265 (29)68 (26)83 (31)114 (43)<0.001
Previous smoker, n (%)261 (29)90 (34)96 (37)75 (29)0.17
History of heart disease, n (%)466 (51)129 (43)151 (50)186 (61)<0.001
  • SBV is calculated as the SD of mean systolic BP measured during five follow-up visits at months 4, 6, 8, 10, and 12. Baseline covariates are measured during initial GFR measurement visit. Twelve-month covariates measured at the 12-month return visit for GFR measurement, BP measurement, and 24-hour urine collection. SBV, systolic BP visit-to-visit variability; mGFR, measured GFR.

  • a Trend testing performed using the Cochrane–Armitage trend test for categorical variables and univariate linear regression for continuous variables, with each individual assigned the mean value of SBV for its tertile of SBV.