Table 3.

Effect of oral sodium bicarbonate on biochemical and inflammatory parameters

ParameterBaselinePlaceboEnd of StudyP Value
IGF-1 (ng/mL)196.46 (175.25, 240.77)208.12 (171.73, 266.86)181.03 (147.37, 214.15)<0.001
IGFBP-1 (μg/mL)3.73 (2.03, 7.48)5.02 (1.80, 9.54)6.97 (1.58, 11.38)0.04
IGFBP-3 (μg/mL)3.06 (2.54, 3.87)2.97 (2.53, 3.56)2.98 (2.43, 3.55)0.43
IGF-1/IGFBP-10.048 (0.031, 0.069)0.030 (0.023, 0.054)0.023 (0.015, 0.064)0.49
IGF-1/IGFBP-30.071 (0.051, 0.084)0.075 (0.042, 0.089)0.061 (0.044, 0.079)0.01
TNF-α (pg/mL)3.33 (1.70, 4.96)3.23 (1.36, 4.79)3.53 (1.74, 4.71)0.98
  • Data are expressed as median (interquartile range). P values were calculated using mixed-effects models separately examining the association of sodium bicarbonate administration with repeated measurements of each parameter. IGFBP, IGF binding protein.