Table 2.

Baseline and final bone histomorphometric features

Bone MeasuresLow Bone TurnoverHigh Bone TurnoverNormal Range
No GHGHCalcitriolCalcitriol + GH
Baseline (n=7)Final (n=5)Baseline (n=7)Final (n=7)Baseline (n=11)Final (n=9)Baseline (n=8)Final (n=6)
Turnover
 Bone formation rate (μm2/μm3 per year)ab7.1 (0.0–13.2)40.8 (40.1, 74.9)15.0 (9.6, 21.8)154.6 (23.7, 174.3c)103.3 (57.0, 173.4)60.3 (20.3, 103.7)c84.9 (67.1, 137.3)85.9 (75.1, 130.5)10–73.4
Mineralization
 Osteoid volume (%)a4.6 (3.7, 7.0)9.5 (9.4, 15.1)5.2 (4.0, 8.1)10.9 (7.4, 14.9)16.3 (13.0, 18.7)13.2 (8.3, 18.3)12.3 (8.9, 14.1)10.6 (9.9, 13.0)0.2–5.86
 Osteoid thickness (µm)a12.2±3.613.4±3.111.1±2.714.5±4.518.0±3.618.2±5.215.4±4.317.8±3.93–13.9
 Osteoid maturation time (d)13 (10, >5000)12 (11, 13)10 (9, 12)13 (11, 14)12 (7, 16)18 (14, 20)11 (10, 13)16 (14, 19)1.9–10.4
 Mineralization lag time (d)ab214 (104, >5000)44 (31, 95)99 (62, 209)24 (22, 42)c33 (23, 44)80 (39, 95)c36 (24, 50)35 (30, 37)4.1–71.7
Volume
 Bone volume (%)23.9±4.821.6±6.424.9±6.527.3±11.828.2±6.230.3±8.324.1±5.732.9±9.69.3–22.7
 Trabecular thickness (µm)a135±17125±31134±29152±46149±29161±29142±22175±2672–177
 Trabecular separation (µm)457±82483±154420±114459±144405±107386±102491±243385±168299–587
 Trabecular number per mm21.72±0.281.73±0.481.90±0.511.69±0.351.87±0.381.88±0.331.75±0.501.90±0.501.3–2.7
  • Normally distributed values are displayed as means ± SD; skewed data are displayed as median (interquartile range). GH, growth hormone.

  • a Significant (P<0.05) baseline difference between patients with high and low bone turnover.

  • b Significant (P≤0.05) difference, adjusting for baseline values, between GH treatment and no GH treatment.

  • c Significant (P≤0.05) difference between baseline and 8 months.