Table 3.

Association of patient and laboratory report characteristics with undocumented CKD

VariableUnadjusted Odds Ratio for Undocumented CKD (95% CI)Odds Ratio for Undocumented CKD Adjusted for Main Effects (95% CI)aAdjusted Odds Ratio for Undocumented CKDb from Analysis with Interaction Term
All SubjectsFrom Stratified AnalysisAll SubjectsFrom Stratified Analysisc
MalesFemalesMalesFemalesSCr onlyeGFRPd
SexSex × report format 0.04
 Females (REF: male)1.75 (1.35, 2.26)2.93 (2.04, 4.21)3.81 (2.43, 5.96)2.14 (1.37, 3.33)
MalesFemales
Laboratory reporting
 SCr only (REF: eGFR)0.97 (0.64, 1.49)0.69 (0.40, 1.20)1.61 (0.99, 2.62)0.89 (0.57, 1.40)0.66 (0.37, 1.16)1.76 (1.02, 3.02)0.64 (0.37, 1.12)1.14 (0.71, 1.86)
eGFR at inclusion (ml/min per 1.73 m2)<0.01
 40–59 (REF: <30)4.17 (2.38, 7.32)5.09 (2.14 12.07)36.13 (3.27, 398.30)9.29 (4.57, 18.87)5.63 (2.34, 13.56)73.3 (8.72, 616.5)9.27 (4.57, 18.78)
 30–44 (REF: <30)3.34 (2.06, 5.39)2.50 (1.16, 5.37)4.14 (2.35, 7.31)4.18 (2.49, 7.03)2.83 (1.30, 6.15)4.74 (2.65, 8.48)4.23 (2.50, 7.18)
Comorbidity
 No DM (REF: DM)1.47 (1.15, 1.90)1.29 (0.86, 1.92)1.48 (1.04, 2.09)1.26 (0.98, 1.62)1.20 (0.82, 1.77)1.23 (0.81, 1.86)1.58 (1.23, 2.03)0.08
 No HTN (REF: HTN)1.50 (1.01, 2.23)1.30 (0.82, 2.08)2.19 (1.15, 4.17)1.53 (1.03, 2.26)1.17 (0.75, 1.83)2.19 (1.13, 4.26)1.62 (1.10, 2.37)0.03
Age (yr)0.03
 <60 (REF: 85+)0.89 (0.50, 1.59)1.16 (0.52, 2.60)0.69 (0.32, 1.49)0.75 (0.41, 1.39)0.98 (0.44, 2.21)0.33 (0.15, 0.72)0.76 (0.41, 1.38)
 60–74 (REF: 85+)0.65 (0.44, 0.94)0.64 (0.39, 1.05)0.62 (0.36, 1.08)0.57 (0.38, 0.86)0.50 (0.28, 0.90)0.60 (0.32, 1.11)0.58 (0.38, 0.88)
 75–84 (REF: 85+)0.97 (0.71, 1.32)1.00 (0.59, 1.68)0.99 (0.63, 1.55)0.97 (0.71, 1.33)0.89 (0.53, 1.53)1.02 (0.62, 1.68)0.99 (0.72, 1.35)
  • CI, confidence interval; SCr, serum creatinine; eGFR, estimated GFR; REF, reference category for odds ratio; DM, diabetes mellitus; HTN, hypertension.

  • a Adjusted for sex, eGFR at inclusion, age, DM, HTN, and report format.

  • b Adjusted for sex, eGFR at inclusion, age, DM, HTN, report format, and sex × eGFR report. If sex × eGFR at inclusion was added to the model, the significance level for the interaction would be P=0.06.

  • c Separate models stratified by sex adjusted for eGFR at inclusion, age, DM, HTN, and report format.

  • d P values are the significance levels for the factors and interaction terms.