Table 1.

Clinical data and status of 166 children with nephrotic syndrome

CharacteristicTotal (n=166)Steroid-Sensitive (n=145)Nonfrequent Relapser (n=106)Nonrelapser (n=49)Infrequent Relapser (n=57)Frequent Relapser (n=32)Steroid-Resistant (n=21)Pa
Sex (male/female)113/5398/4770/3631/1839/1823/915/60.81; 0.67
Onset age (yr)5.1 (3.2–9.5)5.5 (3.5–9.5)6.0 (3.7–9.5)6.9 (4.3–9.2)4.2 (3.2–9.8)4.2 (2.6–7.7)2.9 (2.0–10.7)0.18; 0.05
Proteinuria (g/d per meter2)4.2 (2.7–7.2)4.1 (2.7–7.0)3.8 (2.5–6.5)3.4 (2.7–6.4)4.0 (2.5–6.9)5.6 (3.0–7.8)6.9 (2.8–15.5)0.13; 0.12
Estimated GFR (ml/min per 1.73 m2)111 (95–124)111 (95–124)111 (96–125)115 (97–128)110 (95–119)109 (91–124)109 (96–132)0.93; 0.35
Total protein (g/dl)4.1 (3.8–4.4)4.1 (3.8–4.4)4.1 (3.8–4.5)4.1 (3.8–4.6)4.1 (3.7–4.5)4.0 (3.7–4.3)4.1 (3.6–4.6)0.91; 0.10
Albumin (g/dl)1.6 (1.4–2.0)1.6 (1.4–2.0)1.6 (1.4–2.0)1.7 (1.5–2.1)1.6 (1.4–1.9)1.6 (1.3–1.9)1.7 (1.3–2.3)0.63; 0.24
Serum sodium (mEq/L)138 (135–140)138 (135–140)138 (136–140)139 (137–140)138 (135–140)136 (133–139)137 (134–140)0.36; 0.008
Total cholesterol (mg/dl)430 (346–505)429 (353–505)440 (363–505)398 (333–486)452 (405–511)399 (327–491)452 (304–506)0.83; 0.25
Time from start of initial treatment to disappearance of proteinuria (d)N/A8 (6–10)7 (6–8)7 (5–8)8 (7–9)10 (8–13)N/A<0.001b
Time from start of initial treatment to first relapse (mo)N/AN/AN/AN/A6.1 (3.2–9.6)2.6 (1.5–3.5)N/A<0.001c
  • Data value median (25%–75%) except sex. N/A, not applicable.

  • a P values are steroid-sensitive versus steroid-resistant in left position and nonfrequent relapser versus frequent relapser in right position.

  • b P values are nonfrequent relapser versus frequent relapser.

  • c P values are infrequent relapser versus frequent relapse.