Table 4.

Histologic features of kidney biopsies from normal human kidney donors compared with vascular occlusive disease

Kidney Donors
(n=15 Kidneys)PModerate ARAS
(n=12 Kidneys)PNephrectomy
(n=65 Kidneys)
Glomerular diameter (µm)176.4±220.002138.1±27.9NANAa
174.47 (158.3–196.1)126.9 (117.7–164)
Average glomerular area (µm2)21,236±46830.00213,508±4932NANAa
20,200 (18,680–26,491)12,024 (10,081–18235)
Vessel sclerosis score ≥2 (% of patients)9.10.9516.70.00175
1 (0–1)0.5 (0–1)2 (1.25–3)
Arteriolar sclerosis score ≥2 (% of patients)9.10.758.3<0.001100
1 (1–1)1 (0.25–1)2 (2–3)
Fibrosis (trichrome, %)3.1±1.60.0111.8±13.60.0123.7±12.6
3.2 (1.61–4.38)8.8 (7.2–20.7)22.2 (9.7–38.6)
Tubular atrophy (%)2.4±1.70.1615.7±18.7<0.00164.1±31.5
2 (1–4)7 (3–30)65 (45–93.8)
Inflammation (%)1.1±1.90.1411.5±12.30.0133.3±28.7
0 (0–3)7 (0–25)30 (10–60)
CD68 (cells/hpf)0.8 (0.6–1.6)0.197.2 (1.8–19.7)0.0216.2 (10.3–31.1)
CD3 (cells/hpf)3.8 (2.6–12)0.239.8 (2.9–19.1)0.919.1 (4.8–22)
CD20 (cells/hpf)0.4 (0.2–0.8)0.473.3 (0.7–8.4)0.214.2 (1.2–11)
  • Data are shown as mean ± SD or median (25th–75th percentile) unless otherwise indicated. NA, not applicable; hpf, high-power field.

  • a Extensive glomerular collapse and sclerosis precluded meaningful estimates of diameter and area in these kidneys.