Table 3.

ORs and 95% CIs of elevated serum β-trace protein (≥0.81 mg/L), elevated serum β2-microglobulin (≥2.80 mg/L), and elevated serum cystatin C (≥1.03 mg/L) in persons aged ≥20 years adjusted for eGFR

β-Trace Protein (≥0.81 mg/L)β2-Microglobulin (≥2.80 mg/L)Standard Cystatin C (≥1.03 mg/L)
≥20 yr (n=6682 [1220])≥20 yr (n=6688 [1204])≥20 yr (n=6742 [1680])
OR95% CIPOR95% CIPOR95% CIP
eGFR creatinine0.920.90–0.93<0.010.920.91–0.94<0.010.910.90–0.92<0.01
BMI (per 5 kg/m2 increase)0.800.68–0.950.010.740.66–0.82<0.011.100.96–1.260.15
Hypertension1.991.37–2.90<0.011.701.36–2.14<0.011.711.18–2.460.01
Diabetes1.030.67–1.590.881.510.92–2.470.101.480.96–2.280.08
Current smoker0.890.55–1.440.640.820.54–1.240.341.350.91–2.010.13
CRP (mg/dl)a
 0.22–1.01.260.90–1.780.181.901.39–2.59<0.011.110.85–1.450.42
 >1.02.001.24–3.250.015.703.52–9.24<0.013.522.02–6.15<0.01
Triglycerides (mg/dl)0.560.36–0.880.010.750.55–1.030.071.220.82–1.800.32
HDL (per 10 mg/dl increase)0.820.72–0.94<0.010.800.71–0.90<0.010.840.76–0.92<0.01
Education ≥12 yr0.560.41–0.76<0.010.600.47–0.77<0.010.590.46–0.76<0.01
  • Numbers in brackets represent individuals with an elevated β-trace protein (≥0.81 mg/L) and elevated β2-microglobulin (≥2.80 mg/L). Triglycerides were analyzed on a logarithmic scale (ln). Triglycerides may be converted from mg/dl to mmol/L by multiplying by 0.0113. HDL may be converted from mg/dl to mmol/L by multiplying by 0.0259. OR, odds ratio; 95% CI, confidence interval; eGFR, estimated GFR; BMI, body mass index; CRP, C-reactive protein.

  • a Reference group is individuals with CRP <0.22 mg/dl.