Table 1.

Comparison of 6S and CHEST trials

Characteristic6SCHEST
Total patients (n)7987000
Patients with sepsis (n)7981937
Time from ICU admission to enrollment (h)411
Ratio of HES to crystalloid first 24 h1:11:1.2
Differences in CVP responseNoYes
Carrier solutionRinger’s acetate0.9% saline
Starch originPotatoCorn
Results (HES versus comparator)
 RR for AKI1.03 (0.90–1.17); P=0.70.94 (0.90–0.98); P=0.007
 RR for use of RRT (95% CI)1.35 (1.01–1.80); P=0.041.21 (1.00–1.45); P=0.04
 RR for death by 90 d (95% CI)1.17 (1.01–1.36); P=0.031.06 (0.96–1.18); P=0.26
  • ICU, intensive care unit; HES, hydroxyethyl starch; CVP, central venous pressure; RR, relative risk; RRT, renal replacement therapy; CI, confidence interval.