Table 4.

C statistic and cNRI for each outcome

C StatisticP ValueacNRI (95% CI)
All-cause mortalityeGFRcreatinine0.727
+ ACR0.7320.00123.6 (18.9, 28.4)
+ eGFRcystatin0.7370.00111.9 (6.1, 17.6)
Coronary heart diseaseeGFRcreatinine0.712
+ ACR0.7130.0912.0 (6.8, 17.3)
+ eGFRcystatin0.7160.1117.3 (10.8, 23.7)
Heart failureeGFRcreatinine0.761
+ ACR0.770<0.00118.7 (12.2, 25.2)
+ eGFRcystatin0.7780.00114.0 (6.8, 21.3)
AKIeGFRcreatinine0.754
+ ACR0.7660.00339.5 (31.8, 47.2)
+ eGFRcystatin0.7800.00112.3 (2.8, 21.8)
ESRDeGFRcreatinine0.907
+ ACR0.9160.0832.4 (14.0, 50.8)
+ eGFRcystatin0.9200.3845.7 (28.6, 62.8)
  • Baseline model includes age, race, sex, and total cholesterol, history of diabetes, hypertension, smoking, body mass index, and C-reactive protein. + ACR, baseline model + eGFRcreatinine + ACR; + eGFRcystatin, baseline model + eGFRcreatinine + ACR + eGFRcystatin. cNRI, continuous net reclassification index; 95% CI, 95% confidence interval; eGFR, estimated GFR; ACR, albumin/creatinine ratio.

  • a P value comparing Harrell’s C statistic from the above row.