Table 2.

Improvement in renal function after LVAD implantation

Author (Reference)LVAD TypeParticipants (N)Improvement in Renal FunctionDuration of Follow-Up, Days, Mean (Range)Comments
Burnett et al. (61)Pulsatile11SCr: 3.1 → 1.5115 (31–233)2 of 4 dialysis-dependent patients preimplantation able to discontinue dialysis postimplantation
Farrar et al. (17)Pulsatile22SCr: 1.7 → 1.260–248Patients with continued MOF postimplantation demonstrated worsening of renal function
Bank et al. (60)Pulsatile20SCr: 1.6 → 1.012–193
Frazier et al. (50)Pulsatile271SCr: 1.5 → 1.1112 (1–691)
Khot et al. (62)Pulsatile11SCr: 4.1 → 1.61807 patients were CRRT dependent in peri-implant period. None were CRRT dependent after LVAD implantation at time of death/transplantation
Aaronson et al. (63)Pulsatile13NA8 of 13 CRRT-dependant patients preimplantation recovered renal function postimplantation
Butler et al. (27)Pulsatile220CrCl: 77 → 10728Subset patients’ baseline CrCl <50, 37 → 67 at week 2 postimplant
Russell et al. (46)Continuous78SCr: 1.8 → 1.4180
Kamdar et al. (45)Continuous40SCr: 1.9 → 1.330
Sandner et al. (23)Continuous40eGFR: 42 → 6318065% of patients with baseline eGFR <60 recovered renal function: eGFR 46 → 84
Demirozou et al. (58)Continuous15eGFR: 47 → 6236015 patients required CRRT after LVAD implantation → 10 able to stop RRT by 6 months
Singh et al. (64)Pulsatile and continuous116CrCl: 58 → 74180
Hasin et al. (47)Continuous83eGFR: 53 → 711808 patients required CRRT postimplant: 2 recovered renal function, 2 died, and 4 required chronic hemodialysis
  • LVAD, left ventricular assist device; SCr, serum creatinine (mg/dl); MOF, multiorgan failure; CRRT, continuous renal replacement therapy; NA, not available; CrCl, creatinine clearance (ml/min); eGFR, estimated GFR (ml/min per 1.73 m2).