Table 3.

Joint association of eGFRcreatinine, ACR, and eGFRcystatin with outcomes

All-Cause MortalityCoronary Heart DiseaseHeart FailureAKIESRD
No CKD1.0 (Reference)1.0 (Reference)1.0 (Reference)1.0 (Reference)1.0 (Reference)
CKD stages 1–21.73 (1.44, 2.08)1.07 (0.85, 1.36)1.95 (1.56, 2.45)2.53 (1.88, 3.38)5.02 (2.81, 9.00)
CKD stage 3+1.80 (1.50, 2.15)1.62 (1.31, 2.00)2.47 (2.01, 3.05)3.63 (2.79, 4.74)24.20 (14.86, 39.40)
Multiple marker subcategories
 No CKD1.0 (Reference)1.0 (Reference)1.0 (Reference)1.0 (Reference)1.0 (Reference)
 CKD by eGFRcreatinine only0.96 (0.66, 1.39)0.85 (0.55, 1.31)0.99 (0.60, 1.63)1.61 (0.92, 2.82)3.53 (1.06, 11.68)
 CKD by ACR only1.66 (1.36, 2.04)1.13 (0.88, 1.45)1.85 (1.44, 2.37)2.43 (1.77, 3.33)4.74 (2.52, 8.93)
 CKD by eGFRcystatin only1.67 (1.37, 2.03)1.21 (0.93, 1.58)1.90 (1.49, 2.44)2.44 (1.75, 3.41)3.15 (1.20, 8.30)
 CKD by eGFRcreatinine and eGFRcystatin1.86 (1.42, 2.44)1.85 (1.35, 2.55)2.00 (1.44, 2.80)3.90 (2.65, 5.74)14.57 (6.75, 31.46)
 CKD by eGFRcreatinine and ACR1.26 (0.52, 3.05)1.03 (0.38, 2.76)4.31 (2.28, 8.13)2.19 (0.70, 6.9)8.91 (2.06, 38.49)
 CKD by eGFRcystatin and ACR2.47 (1.70, 3.61)0.93 (0.49, 1.74)3.25 (2.10, 5.03)3.96 (2.18, 7.18)14.55 (5.38, 39.32)
 CKD by all three markers3.69 (2.79, 4.87)3.01 (2.15, 4.20)6.92 (5.14, 9.31)9.78 (6.63, 14.43)125.98 (73.06, 217.22)
  • Data are shown as adjusted hazard ratios (95% confidence intervals). All hazard ratios adjusted for age, race, sex, and total cholesterol, history of diabetes, hypertension, smoking, body mass index, and C-reactive protein eGFR, estimated GFR; ACR, albumin/creatinine ratio.