Table 1.

Baseline risk factors according to presence or absence of doubling of serum creatinine or graft loss during 7 years of follow-up

Risk FactorDSCGL (n=438)No DSCGL (n=1664)P Value
Categorical variables, n (%)
 Women140 (32.0)575 (34.6)0.34
 History of coronary heart disease41 (9.4)160 (9.6)0.93
 Diabetes mellitus96 (21.9)300 (18.0)0.07
 Smoking124 (28.3)265 (15.9)<0.001
 History of left ventricular hypertrophy71 (16.4)240 (14.6)0.37
 Number of transplants0.06 (trend)
  1364 (83.1)1430 (86.0)
  259 (13.5)200 (12.0)
  315 (3.4)33 (2.0)
 Hypertension348 (79.5)1227 (73.7)0.02
 HLA-DR mismatches0.001 (trend)
  0117 (27.8)545 (33.9)
  1214 (50.8)825 (51.3)
  290 (21.4)238 (14.8)
 Treatment for rejections224 (51.7)678 (41.3)<0.001
Continuous variables, mean ± SD
 Age (yr)47.4±10.750.3±10.9<0.001
 LDL cholesterol (mmol/L)4.21±1.064.12±1.010.10
 HDL cholesterol (mmol/L)1.24±0.431.36±0.45<0.001
 Triglycerides (mmol/L)a2.10±1.481.90±1.20<0.001
 Total cholesterol/HDL cholesterol ratio5.90±2.365.28±2.21<0.001
 Time last transplant (mo)a4.96±5.534.40±4.960.011
 Systolic BP (mmHg)149.3± 20.9142.5±18.1<0.001
 Diastolic BP (mmHg)87.2±11.685.2±9.6<0.001
 Body mass index (kg/m2)25.6±4.825.9±4.40.22
 Creatinine (μmol/L)a170.0±84.0127.0±47.0<0.001
 Calcium (mmol/L)2.41±0.162.43±0.160.17
 Phosphate (mmol/L)1.18±0.271.15±0.230.02
 Proteinuria (g/24 hr)a0.38±0.870.15±0.24<0.001
 Hemoglobin (g/dl) (n=1685)13.0±1.9513.65±1.730.007
 LnCRP (mg/L) (n=1913)1.52±4.661.43±4.530.5
  • DSCGL, doubling of serum creatinine or graft loss; LnCRP, natural logarithm of high sensitive C-reactive protein.

  • a Median and inter quartile range.