Table 4.

Changes in mRNA and protein expression of growth factors in vastus lateralis muscle from baseline to week 24

Muscle mRNA (density unit)Oxymetholone (n=19)Placebo (n=22)Difference between Groups in the Mean Change from Baseline (95% CI)
IGF-IEa mRNA
 Baseline0.18±0.080.21±0.09
 Week 240.23±0.160.25±0.10
 Change from baseline0.05±0.180.04±0.090.01 (−0.08 to 0.10)
IGF-IEc × 103 mRNA
 Baseline2.71±2.633.16±3.97
 Week 245.52±6.40a4.27±4.07
 Change from baseline2.81±3.181.11±3.221.71 (−0.33 to 3.73)
IGF-II mRNA
 Baseline5.03±2.095.76±2.61
 Week 245.19±2.885.02±2.69
 Change from baseline0.16±2.47−0.74±2.030.92 (−0.52 to 2.32)
Myostatin mRNA
 Baseline1.06±0.611.14±0.87
 Week 241.40±1.101.05±0.79
 Change from baseline0.33±0.92−0.09±0.870.42 (−0.15 to 0.99)
Myosin heavy-chain 2a mRNA
 Baseline29.84±0.7629.83±0.87
 Week 2430.08±0.1629.99±0.19
 Change from baseline0.24±0.840.15±0.860.09 (−0.45 to 0.63)
Myosin heavy-chain 2× mRNA
 Baseline25.67±17.5734.20±18.84
 Week 2444.60±61.68a29.65±14.12
 Change from baseline18.93±31.51b−4.55±16.9423.48 (6.90–40.06)b
IGF-I receptor mRNA
 Baseline0.45±0.190.45±0.15
 Week 240.48±0.190.36±0.17b
 Change from baseline0.05±0.28b−0.09±0.090.14 (0.01–0.28)b
IGF-II receptor mRNA
 Baseline2.43±0.992.41±0.82
 Week 243.09±2.68a2.12±1.21
 Change from baseline0.66±1.08b−0.29±1.100.95 (0.26–1.64)a
Muscle protein
 IGF-I protein (ng/mg muscle protein)
  Baseline21.84±7.0324.87±8.21
  Week 2423.92±7.2022.01±6.50
  Change from baseline2.08±9.57−2.86±11.444.94 (−1.79 to 11.67)
 IGF-II protein (μg/mg muscle protein)
  Baseline137.11±47.01131.43±52.67
  Week 24163.84±79.66151.47±47.16
  Change from baseline26.73±88.6320.04±68.956.69 (−43.13 to 56.51)
  • Data are mean ± SD. The concentrations of IGF-I and IGF-II protein are expressed as the ratio of IGF protein (nanograms or micrograms) to total protein (milligrams) in the homogenates of muscle tissue. CI, confidence interval.

  • a Compared with placebo: P<0.01.

  • b Compared with placebo: P<0.05.