Table 1.

Characteristics of patients receiving renal replacement therapy in the European Renal Association-European Dialysis and Transplant Association Registry between January 1, 1990, and December 31, 2009

CharacteristicAll PatientsPatients with CAKUT
Prevalence 2009 (pmp)947.544.9
Incidence (n)212,9304,765
Male patients (%)61.561.5
Renal diagnoses (%)
 Hypertensive or diabetic nephropathy46.9
 Unknown/unspecified19.4
 Glomerulonephritis14.4
 Cystic kidney diseases7.1
Vasculitis2.0
Other8.0
CAKUT
 Total2.2100
 Neurogenic PN5.6
 Obstructive PN22.9
 Reflux PN41.9
 Hypoplasia17.3
 Dysplasia12.3
RRT modality (%)
 Hemodialysis80.261.5
 Peritoneal dialysis17.226.1
 Pre-emptive transplantation2.612.4
Mean age at start RRT (yr)
 All61.4±16.635.1±21.0
 Male patients61.2±16.533.1±21.3
 Female patients61.7±16.838.3±20.1a
 1990–199958.4±16.732.9±19.7
 2000–200962.9±16.3a36.6±21.5a
 Neurogenic PN41.8±18.4b,c
 Obstructive PN34.1±21.4c,d
 Reflux PN38.5±18.7c,e
 Hypoplasia35.7±23.9c,e
 Dysplasia22.1±19.7c,f
  • Values expressed with a plus/minus sign are the mean ± SD. CAKUT, congenital anomalies of the kidney and urinary tract; pmp, per million population; PN, pyelonephritis; RRT, renal replacement therapy.

  • a Significant difference between sex or time periods (P<0.001).

  • b Significantly different from patients with obstructive PN, reflux PN, hypoplasia, and dysplasia.

  • c Significant difference (P<0.05).

  • d Significantly different from patients with neurogenic PN, reflux PN, hypoplasia, and dysplasia.

  • e Significantly different from patients with neurogenic PN, obstructive PN, and dysplasia.

  • f Significantly different from patients with neurogenic, obstructive, and reflux PN and hypoplasia.