Table 3.

Health-related quality of life over time in patients treated with hemodialysis and hemodiafiltration

HD (n=356)HDF (n=358)HDF versus HD
ΔP ValueΔP ValueΔP Value
Generic domains (SF-36)
 Physical summary (PCS)−0.8 (−1.1 to −0.5)<0.001a−0.2 (−0.6 to 0.1)0.130.4 (−0.3 to 1.1)0.29
 Mental summary (MCS)0.1 (−0.3 to 0.5)0.78−0.5 (−0.8 to −0.1)0.01a−0.5 (−1.1 to 0.0)0.06
Kidney disease-specific domains
 Symptom/problem list−1.1 (−1.8 to −0.4)0.003a−0.6 (−1.2 to 0.0)0.070.4 (−0.5 to 1.4)0.33
 Effects of kidney disease on daily life−1.3 (−2.3 to −0.4)0.01a−0.3 (−1.1 to 0.4)0.381.1 (−0.1 to 2.4)0.06
 Burden of kidney disease−0.2 (−1.0 to 0.6)0.69−0.9 (−1.7 to −0.1)0.02a−0.7 (−1.7 to 2.4)0.21
 Work status−0.4 (−1.4 to 0.6)0.42−1.1 (−2.0 to −0.1)0.03a−0.6 (−2.0 to 0.8)0.41
 Cognitive function−0.4 (−0.9 to 0.2)0.22−1.1 (−1.7 to −0.4)0.001a−0.7 (−2.0 to 0.7)0.35
 Quality of social interaction−0.1 (−0.9 to 0.6)0.71−0.4 (−1.2 to 0.4)0.36−0.2 (−1.3 to 0.9)0.68
 Sleep0.3 (−0.3 to 0.9)0.350.4 (−0.2 to 1.1)0.170.1 (−0.8 to 1.0)0.76
 Social support−0.2 (−1.1 to 0.7)0.65−0.4 (−1.2 to 1.1)0.37−0.2 (−1.4 to 1.1)0.81
 Dialysis staff encouragement−1.0 (−1.8 to −0.1)0.020.0 (−0.7 to 0.8)0.961.0 (−0.1 to 2.1)0.09
 Overall health0.2 (−0.8 to 1.2)0.690.9 (0.1 to 1.7)0.03a0.7 (−0.5 to 2.0)0.25
 Patient satisfaction−2.5 (−3.4 to −1.5)<0.001a−1.4 (−2.4 to −0.5)0.004a0.0 (0.0 to 0.0)0.29
  • The median follow-up was 2.0 years (interquartile range=1.1–3.0). HD, hemodialysis; HDF, hemodiafiltration; Δ, change in health-related quality of life over time per year; SF-36, Short Form with 36 questions version 1; PCS, the physical composite score; MCS, the mental composite score.

  • a Statistically significant P value.