Table 3.

Performance characteristics for the diagnosis of AKI using estimation methods relative to known baseline: overall and in patients with eGFR < or ≥ 60 ml/min per 1.73 m2

Estimation MethodaSensitivitySpecificityPositive Predictive ValueNegative Predictive Value
 Single eGFR 750.700.910.570.95
 Basic multiple imputation0.570.960.700.93
 Basic multiple imputation + SCr0.550.970.760.93
 Full multiple imputation0.710.920.600.95
 Full multiple imputation + SCr0.570.970.760.93
Patients with eGFR < 60 ml/min per 1.73 m2
 Single eGFR 7510.490.341
 Basic multiple imputation*0.920.780.530.97
 Basic multiple imputation + SCr0.830.870.630.95
 Full multiple imputation0.950.660.420.98
 Full multiple imputation + SCr0.860.840.590.96
Patients with eGFR ≥ 60 ml/min per 1.73 m2
 Single eGFR 750.610.990.870.94
 Basic multiple imputation0.460.990.880.92
 Basic multiple imputation + SCr0.450.990.870.92
 Full multiple imputation0.630.970.750.95
 Full multiple imputation + SCr0.470.990.910.92
  • Estimated GFR based on minimum serum creatinine during the first 7 days of hospitalization. eGFR, estimated GFR; eGFR 75, estimated GFR = 75 ml/min per 1.73 m2; SCr, serum creatinine;.

  • a Basic multiple imputation = three-variable multiple imputation; basic multiple imputation with SCr = basic three-variable multiple imputation plus minimum inpatient serum creatinine; full multiple imputation = full-variable multiple imputation; full multiple imputation with SCr = full variable multiple imputation plus minimum inpatient serum creatinine.