Table 1.

Demographic and physiologic characteristics for all participants and by tertiles of serum FGF-23

CharacteristicAll Patients (n=99)FGF-23P Value
Low (n=33)Intermediate (n=33)High (n=33)
Demographic
 Age (yr)50.0±12.854.0±11.248.4±12.447.7±13.60.09
 Women (%)323040270.55
 Black (%)646464641.00
Baseline
 Diabetes (%)526048470.48
 Cardiovascular disease (%)282430300.82
 Ever smoker (%)525047590.58
 Body mass index (kg/m2)29±629±530±530±70.62
 Systolic BP (mmHg)137±20132±17140±25137±180.30
 Diastolic BP (mmHg)78±1276±1078±1380±130.43
Medication use
 Statins (%)404548270.17
 Antihypertensive medications
   β-blockers625876550.16
  Diuretics383048360.30
  ACE inhibitors or ARBs454236580.20
 Phosphate binders (%)
  Calcium-containing475338500.42
  Non–calcium-containing221334220.11
 Activated vitamin D (%)223122130.19
 Warfarin (n)30030.05
Laboratory assessment
 Total cholesterol (mg/dl)169±38168±34167±33172±470.87
 Parathyroid hormone (pg/ml)253±209213±116296±243253±2410.28
 Phosphate (mg/dl)4.6±1.33.9±1.04.6±1.25.3±1.4<0.001
 Calcium (mg/dl)8.8±1.18.7±0.98.7±1.09.0±1.20.53
 25-OH vitamin D (ng/ml)26.1±15.127.3±14.523.9±15.526.9±15.70.62
 Albumin (g/dl)3.5±0.63.5±0.63.5±0.53.5±0.60.90
 Median hsCRP (mg/L) (IQR)6.4 (2.6–13.9)7.0 (3.0–13.5)8.8 (1.5–15.1)4.8 (2.7–10.5)0.61
 Median FGF-23 (RU/mL) (IQR)1238 (515–2218)432 (383–515)1238 (958–1459)3659 (2218–5238)<0.001
Baseline coronary calcium assessment
 Median baseline Agatston score (Agatston units) (IQR)26.0 (0–274.6)26.0 (0–158.8)16.0 (0–368.0)58.5 (0–310.1)0.81
 Median baseline calcium volume score (IQR)28.4 (0–210.7)25.2 (0–143.4)15.9 (0–270.0)48.1 (0–256.6)0.81
  • Clinical characteristics are expressed as mean ± SD, percentage, or median (interquartile range), where appropriate. ACE, angiotensin-converting enzyme; ARB, angiotensin-receptor blocker; hsCRP, high-sensitivity C-reactive protein; IQR, interquartile range.