Table 2.

Diagnostic capability of serum and urine tests for cast nephropathy

SensitivitySpecificityPPVNPVAUC ROC
%UAE0.99
 220.980.940.780.990.96
 250.980.940.750.990.98
 271.00.920.711.00.96
Urine protein (g/d)0.76
 3.00.720.700.320.930.71
 4.00.810.640.310.950.73
 5.00.880.520.270.960.70
Urine M-spike (g/d)0.91
 0.020.980.800.490.990.85
 0.050.950.810.490.990.87
 0.10.930.820.500.980.87
Serum albumin (g/dl)0.79
 2.60.880.560.310.910.71
 2.70.860.640.320.960.75
 2.90.740.720.500.930.73
Serum creatinine (mg/dl)0.87
 2.40.990.700.380.990.82
 2.60.910.720.390.980.81
 2.80.840.770.460.950.79
  • The middle values represent the best cutoff for each test which was calculated by ROC analysis. PPV, positive predictive value; NPV, negative predictive value; AUC, area under the curve; ROC, receiver operator characteristics; %UAE, percentage of urine albumin excretion; M-spike, monoclonal spike.