Table 1.

Patient characteristics

ATNALLCDDCNP Value
n12772843
Age (yr)64 (51–83)61 (36–82)56 (38–83)62 (29–81)0.18
Male sex (%)41.764.967.965.10.44
FLC ratio454 (4.1–15333)9 (1.1–415)53 (1.1–7178)430 (3.3–8026)<0.001
serum creatinine (mg/dl)3.5 (1.7–8.0)1.4 (0.6–7.1)2.8 (1.3–10.2)4.9 (1.4–12.5)<0.001
Serum albumin (g/dl)3.9 (2.6–4.6)2.2 (0.8–3.5)3.3 (2.2–4)3.1 (2.1–4.9)<0.001
Urine protein (g/d)1.2 (0.1–12.2)5.8 (0.7–70.3)2.5 (0.1–10.1)2.0 (0.1–19.7)<0.001
Urine M-spike (g/d)0.26 (0.02–1.2)0.34 (0.02–2.5)0.76 (0.0–2.7)1.0 (0.05–17.9)0.01
%UAE25 (8–62)70 (5–81)55 (7–78)7 (2–26)<0.001
κ (%)70.019.580.057.1<0.001
  • Differences were calculated using ANOVA. ATN, acute tubular necrosis; AL, Ig light chain amyloidosis; LCDD, light chain deposition disease; CN, cast nephropathy; FLC, serum free light chain; M-spike, monoclonal spike; %UAE, percentage of urine albumin excretion.