Table 3.

Adjusted estimates and 95% confidence intervals of the difference in common carotid artery intima-media thickness (in micrometers) per specified differences in lipid particle concentrations according to level of kidney function and presence of inflammation

Lipid ParticleeGFR ≥60 (n=5719)aPbeGFR<60 (n=853)cPb
No Inflammation
(n=4726)Inflammation
(n=993)No Inflammation
(n=670)Inflammation
(n=183)
Total cholesterol per 10 mg/dl0.28<0.01
 <200 mg/dl2.51 (0.02, 5.00)5.71 (0.62, 10.81)1.88 (−6.35, 10.13)−25.90 (−45.53, −6.48)
 ≥200 mg/dl5.65 (3.08, 8.23)1.23 (−5.01, 7.48)8.35 (1.07, 16.60)38.18 (13.87, 62.49)
LDL-C per 10 mg/dl0.65<0.001
 <130 mg/dl4.41 (1.77, 7.05)5.17 (−0.52, 10.87)4.52 (-4.32, 13.37)−26.02 (−48.70, −3.35)
 ≥130 mg/dl5.44 (2.52, 8.37)2.04 (−5.47, 9.56)10.07 (0.63, 19.51)42.04 (10.58, 73.50)
Log HDL-C−14.15 (−35.90, 7.60)−52.95 (−102.09, −3.81)0.20−45.39 (−115.92, 25.13)−42.72 (−240.86, 155.4)0.96
Log triglycerides3.02 (−7.99, 14.03)10.69 (−14.94, 36.31)0.489.70 (−27.83, 47.22)−16.90 (−128.97, 95.19)0.30
NMR lipids
 Small-dense LDL per 100 nmol/L5.08 (3.25, 6.92)3.28 (−0.01, 7.39)0.897.62 (1.42, 13.82)3.10 (−14.59, 20.77)0.61
 Large LDL per 100 nmol/l5.85 (3.50, 8.19)7.45 (2.26, 12.63)0.8916.45 (8.32, 24.58)0.60 (−19.86, 21.04)0.18
 Log IDL cholesterol0.27 (−4.13, 4.67)2.15 (−9.63, 13.94)0.66−4.88 (−20.91, 11.14)43.66 (−7.64, 94.96)0.38
  • Adjusted for age (years), sex, race/ethnicity, lipid-lowering medication use, presence of diabetes mellitus, presence of hypertension, log-transformed body mass index, log-transformed urinary albumin/creatinine ratio, and smoking status (current, former, never smoker). Inflammation is defined as the ≥90th percentile of either IL-6 (≥3 pg/ml) or high-sensitivity C-reactive protein (≥9 mg/L). eGFR, estimated GFR; LDL-C, LDL cholesterol; HDL-C, HDL cholesterol; IDL, intermediate density lipoprotein.

  • a No inflammation (<200, n=2775; ≥200, n=1951) and inflammation (<200, n=622; ≥200, n=371) for total cholesterol; no inflammation (<130, n=3142; ≥130, n=1584) and inflammation (<130, n=709; ≥130, n=284) for LDL-C.

  • b P values are for interaction.

  • c No inflammation (<200, n=391; ≥200, n=279) and inflammation (<200, n=122; ≥200, n=61) for total cholesterol; no inflammation (<130, n=462; ≥130, n=208) and inflammation (<130, n=134; ≥130, n=49) for LDL-C.