Lipid Particle | eGFR ≥60
(n=5719) | eGFR <60
(n=853) | P for Interaction^{a} |
---|---|---|---|

Total cholesterol per 10 mg/dl^{b} | 0.01 | ||

<200 mg/dl | 2.97 (0.71, 5.23) | −4.89 (−12.98, 3.20) | |

≥200 mg/dl | 4.79 (2.40, 7.18) | 13.13 (4.82, 21.42) | |

LDL-C per 10 mg/dl^{c} | 0.01 | ||

<130 mg/dl | 4.65 (2.27, 7.04) | −2.53 (−11.46, 6.09) | |

≥130 mg/dl | 4.76 (2.05, 7.47) | 15.91 (6.34, 25.49) | |

Log HDL-C | −21.41 (−41.00, −1.57) | −58.49 (−126.61, 9.63) | 0.10 |

Log triglycerides | 4.65 (−5.41, 14.72) | −2.58 (−38.97, 33.82) | 0.42 |

NMR lipids | |||

Small-dense LDL per 100 nmol/L | 4.83 (3.16, 6.50) | 7.48 (1.45, 13.50) | 0.12 |

Large-dense LDL per 100 nmol/L | 6.21 (4.08, 8.34) | 12.18 (4.51, 19.86) | 0.81 |

Log IDL | 0.53 (−3.59, 4.65) | 2.99 (−12.88, 18.86) | 0.78 |

Adjusted for age (years), sex, race/ethnicity, lipid-lowering medication use, presence of diabetes mellitus, presence of hypertension, log-transformed body mass index, log-transformed urinary albumin/creatinine ratio, smoking status (current, former, never smoker), log-transformed high-sensitivity C-reactive protein, and log-transformed IL-6. eGFR, estimated GFR (ml/min per 1.73 m

^{2}); LDL-C, LDL cholesterol; HDL-C, HDL cholesterol; NMR, nuclear magnetic resonance; IDL, intermediate density lipoprotein.↵a

*P*values testing for the null hypothesis that all slopes across eGFR strata are identical in linear spline models.↵b Continuous estimates presented before and after a linear spline knot at 200 mg/dl for eGFR ≥60 (<200,

*n*=3397; ≥200,*n*=2322) and for eGFR <60 (<200,*n*=513; ≥200,*n*=340).↵c Continuous estimates presented before and after a linear spline knot at 130 mg/dl for eGFR ≥60 (<130,

*n*=3851; ≥130,*n*=1868) and for eGFR <60(<130,*n*=596; ≥130,*n*=257).