Table 2.

Adjusted estimates and 95% confidence intervals of the difference in common carotid artery intima-media thickness (in micrometers) per specified differences in lipid particle concentrations, by level of kidney function

Lipid ParticleeGFR ≥60
(n=5719)eGFR <60
(n=853)P for Interactiona
Total cholesterol per 10 mg/dlb0.01
 <200 mg/dl2.97 (0.71, 5.23)−4.89 (−12.98, 3.20)
 ≥200 mg/dl4.79 (2.40, 7.18)13.13 (4.82, 21.42)
LDL-C per 10 mg/dlc0.01
 <130 mg/dl4.65 (2.27, 7.04)−2.53 (−11.46, 6.09)
 ≥130 mg/dl4.76 (2.05, 7.47)15.91 (6.34, 25.49)
Log HDL-C−21.41 (−41.00, −1.57)−58.49 (−126.61, 9.63)0.10
Log triglycerides4.65 (−5.41, 14.72)−2.58 (−38.97, 33.82)0.42
NMR lipids
 Small-dense LDL per 100 nmol/L4.83 (3.16, 6.50)7.48 (1.45, 13.50)0.12
 Large-dense LDL per 100 nmol/L6.21 (4.08, 8.34)12.18 (4.51, 19.86)0.81
 Log IDL0.53 (−3.59, 4.65)2.99 (−12.88, 18.86)0.78
  • Adjusted for age (years), sex, race/ethnicity, lipid-lowering medication use, presence of diabetes mellitus, presence of hypertension, log-transformed body mass index, log-transformed urinary albumin/creatinine ratio, smoking status (current, former, never smoker), log-transformed high-sensitivity C-reactive protein, and log-transformed IL-6. eGFR, estimated GFR (ml/min per 1.73 m2); LDL-C, LDL cholesterol; HDL-C, HDL cholesterol; NMR, nuclear magnetic resonance; IDL, intermediate density lipoprotein.

  • a P values testing for the null hypothesis that all slopes across eGFR strata are identical in linear spline models.

  • b Continuous estimates presented before and after a linear spline knot at 200 mg/dl for eGFR ≥60 (<200, n=3397; ≥200, n=2322) and for eGFR <60 (<200, n=513; ≥200, n=340).

  • c Continuous estimates presented before and after a linear spline knot at 130 mg/dl for eGFR ≥60 (<130, n=3851; ≥130, n=1868) and for eGFR <60(<130, n=596; ≥130, n=257).