Table 2.

Independent associations between baseline characteristics, ESRD, and pre-ESRD death

ESRDPre-ESRD Mortality
Cox ModelCompeting Risks ModelCox ModelCompeting Risks Model
Hazard Ratio
(95% CI)P ValueSubhazard Ratio
(95% CI)P ValueHazard Ratio (95% CI)P ValueSubhazard Ratio
(95% CI)P Value
Vascular disease1.11 (0.91–1.36)0.300.82 (0.60–1.13)0.201.63 (1.20–2.20)0.0021.57 (1.15–2.14)0.004
Agea0.86 (0.81–0.91)<0.0010.80 (0.75–0.86)<0.0012.15 (1.81–2.56)<0.0012.13 (1.81–2.51)<0.001
Female sex0.92 (0.81–1.04)0.200.94 (0.81–1.09)0.400.79 (0.60–1.04)0.100.87 (0.66–1.14)0.30
African-American race1.08 (0.90–1.31)0.400.92 (0.70–1.20)0.501.48 (1.01–2.16)0.041.31 (0.89–1.93)0.20
Current smoker1.30 (1.09–1.55)0.0041.14 (0.93–1.41)0.201.50 (1.01–2.23)0.041.37 (0.92–2.03)0.10
Systolic BPb1.04 (1.00–1.08)0.061.02 (0.98–1.08)0.901.09 (1.02–1.17)0.011.05 (0.98–1.13)0.20
Diabetes status1.47 (1.12–1.93)0.010.97 (0.64–1.46)0.902.13 (1.42–3.19)<0.0011.54 (1.03–2.32)0.04
PKDc3.04 (2.60–3.54)<0.0013.07 (2.49–3.77)<0.0010.52 (0.30–0.91)0.020.30 (0.17–0.52)<0.001
Glomerular diseasec0.98 (0.84–1.14)0.801.09 (0.91–1.31)0.300.96 (0.69–1.34)0.801.01 (0.72–1.41)0.90
Log-proteinuria2.00 (1.81–2.21)<0.0011.77 (1.59–1.98)<0.0011.19 (0.97–1.46)0.100.71 (0.57–0.88)0.002
Estimated GFRd1.62 (1.56–1.70)<0.0011.55 (1.47–1.64)<0.0011.18 (1.08–1.29)<0.0010.92 (0.86–0.99)0.03
  • 95% CI, 95% confidence interval; PKD, polycystic kidney disease;

  • a Per decade increase.

  • b Per 10 mmHg increase.

  • c Reference: Other cause of kidney disease.

  • d Per 10 ml/min per 1.73 m2 lower.