Table 1.

Demographic and clinical characteristics of 6572 participants in the MESA cohort by levels of kidney function

CharacteristiceGFR ≥60
(n=5719)eGFR 45–59
(n=709)eGFR <45
(n=144)P for Differencea
Male sex2721 (48)311 (44)66 (46)0.17
Race<0.001
 Black1600 (28)168 (24)45 (32)
 Chinese689 (12)80 (11)14 (10)
 Hispanic1294 (23)111 (16)30 (21)
 White2136 (37)350 (49)55 (38)
Age (yr)60 (53–68)71 (65–77)75 (68–79)<0.001
Body mass index (kg/m2)27.5 (24.4–31.1)27.6 (24.7–31.2)28.3 (25.2–31.9)0.14
Current smoker782 (14)45 (6)10 (7)<0.001
Diabetes679 (12)95 (13)35 (24)<0.001
 Biguanide use280 (5)41 (6)4 (3)
 Sulfonylurea use297 (5)46 (6)13 (9)
Hypertension2353 (41)453 (64)123 (85)<0.001
 Angiotensin converting enzyme inhibitor use168 (3)41 (6)15 (10)
 β-blocker use447 (8)103 (15)29 (20)
Use of any lipid-lowering medication836 (15)176 (25)41 (29)<0.001
 Statin use771 (13)162 (23)37 (26)
Lipid levels (mg/dl)
 Total cholesterol192 (170–215)192 (170–216)191 (169–216)0.95
 LDL-C116 (96–136)113 (95–137)113 (93–135)0.30
 HDL-C48 (41–59)50 (41–60)44 (37–57)<0.001
 Triglycerides109 (77–157)116 (81–162)122 (91–189)<0.001
Lipoprotein particle concentration (nmol/L)
 Small-dense LDL518 (113–798)489 (105–776)563 (122–817)0.06
 Large LDL601 (426–764)596 (414–775)518 (380–692)0.03
 IDL102 (51–175)112 (53–175)117 (51–188)0.14
High-sensitivity C-reactive protein (mg/L)1.8 (0.8–4.2)2.1 (1.0–4.5)2.6 (1.3–5.7)<0.001
IL-6 (pg/ml)1.2 (0.7–1.8)1.4 (1.0–2.1)1.5 (1.1–2.2)<0.001
Urinary albumin/creatinine ratio (mg/g)5.1 (3.3–10.1)6.2 (3.6–14.8)16.4 (4.5–107.8)<0.001
Intima-media thickness (μm)830 (730–960)910 (800–1040)940 (830–1060)<0.001
  • Data are n (%) or median (interquartile range). MESA, Multi-Ethnic Study of Atherosclerosis; eGFR, estimated GFR (ml/min per 1.73 m2); LDL-C, LDL cholesterol; HDL-C, HDL cholesterol; IDL, intermediate density lipoprotein.

  • a P values based on Fisher’s exact test and the Kruskal–Wallis test for categorical and continuous variables, respectively.