Table 6.

Whole-urine protein receiver-operating characteristic curve analysis

Protein per LevelSensitivitySpecificityAUC (95% CI)
AQP20.497 (0.26–0.73)
 0.210.9170.077
 0.370.50.538
 1.190.1670.615
VATPase0.692 (0.48–0.91)
 1.590.9170.154
 13.730.6670.769
 29.30.1670.923
TGFβ0.788 (0.60–0.98)
 1.590.9170.077
 2.700.8330.615
 7.600.3330.923
N-cadherin0.5 (0.26–0.74)
 1.660.8330.231
 2.690.6670.538
 6.280.1670.769
TRPV40.599 (0.37–0.83)
 0.620.9170.077
 2.310.50.692
 8.600.0830.923
L1CAM0.795 (0.61–0.98)
 1.320.9170.077
 2.820.8330.692
 6.060.4170.846
Urinary protein-to-creatinine ratio0.814 (0.65–0.98)
 11.550.9170.231
 43.500.8330.692
 69.250.4170.923
eGFR
 36.00.4171.000.976 (0.80–1.00)
 59.00.751.00
 94.51.00.25
  • All protein levels are expressed in arbitrary units, urinary protein-to-creatinine as g/mol, and eGFR as ml/min per 1.73 m2. AUC, area under the receiver-operating characteristic curve; CI, confidence interval; AQP2, aquaporin-2; VATPase, vacuolar-type H+-adenosine triphosphatase; TRPV4, transient receptor potential cation channel subfamily V member 4; L1CAM, L1 cell adhesion molecule.