Table 1.

Baseline demographic characteristics and laboratory data in patients with different types of primary glomerulonephritis

Demography and BiochemistryTotal (n=580)FSGS (n=132)IgAN (n=130)MCD (n=109)MN (n=209)P Valuea
Age (years)44.4±16.844.3±15.134.5±12.135.7±15.955.2±14.3<0.001
Male (%)58.557.646.963.363.60.02
Diabetes (%)7.98.32.34.613.90.002
Hypertension (%)32.548.525.421.133.0<0.001
Serum albumin (g/dl)3.0±1.03.2±1.03.9±0.72.7±1.22.5±0.7<0.001
Hemoglobin (g/dl)13.0±2.212.8±2.112.5±2.314.2±1.912.7±2.1<0.001
BUN (mg/dl)22.9±17.630.1±20.324.2±22.219.7±13.019.0±12.3<0.001
Serum creatinine (mg/dl)1.5±1.31.8±1.31.8±1.71.2±0.91.3±1.2<0.001
eGFR (ml/min per 1.73 m2)70.4±33.856.8±33.763.4±32.787.3±34.074.6±29.6<0.001
  ≥90 (%)27.613.517.748.631.6<0.001
 60–89 (%)34.125.635.433.139.7<0.001
 30–59 (%)25.539.929.211.921.1<0.001
 15–29 (%)8.816.58.54.66.2<0.001
 <15 (%)4.04.59.21.81.4<0.001
Serum cholesterol (mg/dl)311±151288±159217±78414±198328±109<0.001
Serum triglyceride (mg/dl)223±161245±172133±72246±152252±178<0.001
Proteinuria
 mild (1+ or 2+; %)28.731.156.325.911.6<0.001
 severe (>3.5g/d or ≥3+; %)71.368.943.774.188.4<0.001
Steroid treatment alone (%)42.019.730.064.252.2<0.001
Other cytotoxic agents alone (%)11001
Combined treatment of steroid and cytotoxic agents (%)18.130.06.28.323.0<0.001
Intervals between onset of disease and date of biopsy (days)12.710.310.712.815.4<0.001
  • FSGS, focal and segmental glomerulosclerosis; IgAN, IgA nephropathy; MCD, minimal change disease; MN, membranous nephropathy; eGFR, estimated GFR as calculated by the simplified Modification of Diet in Renal Disease formula: 186×(creatinine [mg/dl])−1.154×(age [years])−0.203×0.742 (if female).

  • a All P values were obtained from one-way ANOVA for testing the equality in population means among the FSGS, IgAN, MCD, and MN groups of patients.