Table 3.

BP measurements before and after 8 weeks of maximally tolerated carvedilol among 25 participants with intradialytic hypertension

Baseline (n=25)Study End (n=25)Mean Change from Baseline to Study endP Value
2-wk frequency of intradialytic hypertension (%)77% (4.6 of 6 sessions)28% (1.7 of 6 sessions)49% (2.9 of 6 sessions)<0.001
2-wk average BP (mmHg)a
 predialysis systolic144.0 (±9.7)146.1 (±14.4)2.2 (±16.9)0.5
 postdialysis systolic159.0 (±9.3)142.4 (±12.7)−16.7 (±16.7)<0.001
 predialysis diastolic77.5 (±9.2)75.9 (±8.9)−1.6 (±9.6)0.4
 postdialysis diastolic80.9 (±7.6)72.5 (±23.9)−8.4 (±22.8)0.08
 Δ systolic (postdialysis–predialysis)+15.0 (±9.1)−3.8 (±16.1)−18.8 (±16.5)<0.001
Ambulatory BP (mmHg)
 systolic (44-hr)155.4 (±14.2)147.7 (±16.2)−7.5 (±16.8)0.04
  daytime systolic155.7 (±14.9)146.9 (±15.9)−8.2 (±18.5)0.04
  nighttime systolic155.6 (±16.4)149.8 (±19.7)−4.1 (±18.2)0.3
 diastolic (44-hr)82.4 (±10.8)77.7 (±9.7)−4.2 (±7.7)0.01
  daytime diastolic83.2 (±11.8)77.6 (±9.7)−4.7 (±8.8)0.02
  nighttime diastolic80.9 (±10.6)77.0 (±11.1)−2.8 (±7.3)0.09
Central aortic BP (mmHg)
 systolic153.7 (±30.8)147.3 (±34.8)−6.4 (±25.7)0.2
 diastolic76.1 (±11.5)75.6 (±12.4)−0.5 (±10.2)0.8
  • Values are reported as mean ± SD or n (%). P values determined from paired t tests

  • a Values are 2-week averages of BP from the six hemodialysis sessions before intervention and the six hemodialysis sessions at study end.