Multivariate Cox proportional hazards analysis for relative risk of cardiovascular and overall mortality calculated for DcR3 tertiles and for a 1-SD unit change in log DcR3 levels in a follow-up of 54 months
| Cardiovascular Mortality | All-Cause Mortality | |||||
|---|---|---|---|---|---|---|
| Hazard Ratio (95% Confidence Interval) | Hazard Ratio (95% Confidence Interval) | |||||
| Crude | Age- and Sex-Adjusted | Multivariate Adjustment | Crude | Age- and Sex-Adjusted | Multivariate Adjustment | |
| DcR3 by tertiles | ||||||
| lower tertile | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| middle tertile | 1.4 (0.5−3.9) | 1.3 (0.4−3.6) | 1.3 (0.5−3.8) | 1.6 (0.9−2.8) | 1.5 (0.8−2.6) | 1.4 (0.9−2.5) |
| upper tertile | 3.6 (1.5−8.6) | 3.0 (1.2−7.2) | 2.8 (1.1−7.3) | 2.9 (1.7−4.9) | 2.5 (1.4−4.2) | 2.1 (1.1−3.7) |
| P for trend | 0.002 | 0.007 | 0.04 | <0.001 | 0.001 | 0.02 |
| Log DcR3 | ||||||
| 1-SD unit increase | 1.7 (1.2−2.6) | 1.6 (1.2−2.4) | 1.4 (1.1−2.1) | 1.7 (1.3−2.1) | 1.6 (1.2−2.0) | 1.3 (1.1−1.7) |
| P value | 0.007 | 0.03 | <0.05 | <0.001 | 0.001 | 0.04 |
Hazard ratios and 95% confidence intervals were derived from Cox regression analysis with DcR3 taken into account as a time-dependent covariate. The multivariate model included variables for age, sex, smoking status, diabetes, prior cardiovascular disease, body mass index, total cholesterol, systolic BP, hemodialysis duration, urea Kt/V, serum albumin, hemoglobin, IL-6, and vascular cell adhesion molecule-1. DcR3, decoy receptor 3.