Table 4.

Multivariate Cox proportional hazards analysis for relative risk of cardiovascular and overall mortality calculated for DcR3 tertiles and for a 1-SD unit change in log DcR3 levels in a follow-up of 54 months

Cardiovascular MortalityAll-Cause Mortality
Hazard Ratio (95% Confidence Interval)Hazard Ratio (95% Confidence Interval)
CrudeAge- and Sex-AdjustedMultivariate AdjustmentCrudeAge- and Sex-AdjustedMultivariate Adjustment
DcR3 by tertiles
 lower tertile1.01.01.01.01.01.0
 middle tertile1.4 (0.5−3.9)1.3 (0.4−3.6)1.3 (0.5−3.8)1.6 (0.9−2.8)1.5 (0.8−2.6)1.4 (0.9−2.5)
 upper tertile3.6 (1.5−8.6)3.0 (1.2−7.2)2.8 (1.1−7.3)2.9 (1.7−4.9)2.5 (1.4−4.2)2.1 (1.1−3.7)
 P for trend0.0020.0070.04<0.0010.0010.02
Log DcR3
 1-SD unit increase1.7 (1.2−2.6)1.6 (1.2−2.4)1.4 (1.1−2.1)1.7 (1.3−2.1)1.6 (1.2−2.0)1.3 (1.1−1.7)
 P value0.0070.03<0.05<0.0010.0010.04
  • Hazard ratios and 95% confidence intervals were derived from Cox regression analysis with DcR3 taken into account as a time-dependent covariate. The multivariate model included variables for age, sex, smoking status, diabetes, prior cardiovascular disease, body mass index, total cholesterol, systolic BP, hemodialysis duration, urea Kt/V, serum albumin, hemoglobin, IL-6, and vascular cell adhesion molecule-1. DcR3, decoy receptor 3.