Table 1.

Patients’ characteristics according to tertiles of DcR3 levels

Characteristic Serum DcR3 TertilesP Value
0.05−0.92 ng/ml (n=105)0.93−2.41 ng/ml (n=105)2.45−17.78 ng/ml (n=106)
Age (yr)58±1259±1461±130.06a
Male sex48 (45.7)52 (49.5)50 (47.2)0.86b
Smoking history35 (33.3)32 (30.5)35 (33.0)0.89b
Hypertension47 (44.8)46 (43.8)52 (49.1)0.72b
Diabetes mellitus33 (31.4)36 (34.3)35 (33.0)0.91b
Previous CVD15 (14.3)21 (20.0)30 (28.6)0.04b
Hemodialysis vintage (mo)72 (37–131)76 (36–120)61 (26–118)0.34c
Body mass index (kg/m2)22.1±3.422.3±3.122.1±4.20.87a
Systolic BP (mmHg)134±26134±22138±240.40a
Diastolic BP (mmHg)75±1575±1076±110.73a
RAS blockade27 (25.7)30 (28.6)29 (27.3)0.90b
Total no. of antihypertensives3 (0–4)3 (0–3)4 (0–5)0.67c
Statin16 (15.2)15 (14.3)19 (17.9)0.75b
Laboratory parameters
 Kt/V urea2.10±0.482.05±0.412.01±0.740.58a
 albumin (g/dl)4.01±0.313.95±0.413.79±0.35<0.001a
 hs-CRP (mg/L)3.75 (1.30–6.39)3.86 (1.52–8.24)5.70 (2.23–8.81)0.01c
 IL-6 (pg/ml)2.79 (1.66–5.53)4.09 (2.20–4.09)5.36 (2.52–14.4)<0.001c
 ICAM-1 (ng/ml)431 (333–599)511 (385–738)668 (437–818)0.02c
 VCAM-1 (ng/ml)1903 (1491–2391)2139 (1585–2798)2550 (1672–3771)0.04c
 plasma glucose (mg/dl)113±28112±29110±290.90a
 total cholesterol (mg/dl)193±48192±45192±470.90a
 triglyceride (mg/dl)190 (182–248)188 (181–260)189 (184–237)0.88c
 calcium (mg/dl)9.7±0.79.6±0.99.6±0.80.62a
 phosphate (mg/dl)5.1±1.35.2±1.54.9±1.30.21a
 intact PTH (pg/ml)254 (109–421)217 (94–530)202 (65–468)0.81c
 hemoglobin (g/dl)10.6±1.510.6±1.610.3±1.60.30a
 dose of epoetin (U/kg per week)71 (30–99)68 (33–94)71 (20–95)0.67c
 ferritin (μg/L)288 (160–452)322 (182–492)346 (196–585)0.29c
 transferrin saturation (%)25±1225±1126±140.68a
  • All variables were expressed as n (%) for categorical data and as means ± SD or medians and interquartile ranges for continuous data with or without a normal distribution, respectively. Previous CVD category consisted of coronary artery disease, cerebrovascular disease, and peripheral arterial disease. DcR3, decoy receptor 3; CVD, cardiovascular disease; RAS, renin-angiotensin system; hs-CRP, high-sensitivity C-reactive protein; ICAM-1, intercellular adhesion molecule-1; VCAM-1, vascular cell adhesion molecule-1; PTH, parathyroid hormone.

  • a Statistical analysis by ANOVA.

  • b Statistical analysis by the Pearson chi-squared test.

  • c Statistical analysis by the Kruskal–Wallis test.