Table 3.

Summary of pharmacokinetic parameters grouped according to residual renal function

ParameterTotalAnuricNonanuricP Valuea
F0.76 (0.69–0.82)0.76 (0.70–0.82)0.78 (0.69–0.84)0.98
Cmax, plasma (mg/L)3.12 (2.44–3.36)2.86 (2.22–3.20)3.15 (2.54–3.53)0.43
Cmin, plasma (mg/L)1.89 (1.42–2.15)1.88 (1.46–2.15)1.97 (1.38–2.19)0.88
AUCplasma 0–24 (mg⋅h/L)60.45 (37.78–65.66)58.14 (39.92–65.83)60.45 (26.59–65.66)0.56
Cmax, peritoneal (mg/L)23.75 (20–26)23.75 (20.5–27.5)23.75 (20–26)0.91
Cmin, peritoneal (mg/L)1.52 (1.25–2.00)1.38 (1.15–1.58)1.82 (1.49–2.11)0.10
AUCperitoneal 0–24 (mg⋅h/L)121.92 (108.77–145.16)121.44 (108.58–148.86)125.74 (108.77–145.16)1.00
kel×10(h−1)0.30 (0.20–0.30)0.25 (0.20–0.30)0.30 (0.30–0.40)0.01
t1/2, el (h)24.71 (20.37–29.89)28.78 (24.54–30.77)21.10 (18.90–27.14)0.03
kpc 0–6 (h−1)0.23 (0.19–0.26)0.22 (0.19–0.26)0.24 (0.19–0.27)0.62
t1/2, pc 0–6 (h)2.98 (2.69–3.59)3.19 (2.69–3.59)2.88 (2.60–3.60)0.62
t1/2, eq (h)2.89 (2.38–3.13)2.87 (2.48–3.04)3.03 (2.38–3.79)0.77
Vd (L/kg)0.30 (0.20–0.36)0.31 (0.26–0.42)0.22 (0.17–0.32)0.20
CLtotal (L/h)0.25 (0.22–0.27)0.25 (0.23–0.31)0.24 (0.19–0.26)0.44
CLplasma 0–24 (L/h)0.54 (0.46–0.64)0.58 (0.50–0.66)0.43 (0.37–0.58)0.12
CLperitoneal 6–24 (L/h)0.26 (0.25–0.28)0.25 (0.24–0.28)0.27 (0.26–0.28)0.18
CLnondial (L/h)0.31 (0.14–0.39)0.33 (0.26–0.39)0.14 (0.14–0.31)0.14
  • All values are reported as median (interquartile range). F, fraction of intraperitoneal dose absorbed; Cmax, plasma, peak plasma concentration; Cmin, plasma, trough plasma concentration at 24 hours; AUCplasma 0–24, area under the plasma concentration time curve between 0 and 24 hours; Cmax, peritoneal, peak concentration in peritoneal dialysate during the intraperitoneal antibiotic dwell; Cmin, peritoneal, trough concentration in peritoneal dialysate at 24 hours; AUCperitoneal 0–24, area under the peritoneal dialysate concentration time curve between 0 and 24 hours; kel, plasma elimination rate constant; t1/2, el, plasma elimination half-life; kpc 0–6, rate constant for distribution of drug from the peritoneal cavity between 0 and 6 hours; t1/2, pc 0–6, distribution half-life in the peritoneal cavity between 0 and 6 hours; t1/2, eq, equilibration half-life; Vd, volume of distribution; CLtotal, total clearance from the systemic circulation; CLplasma 0–24, plasma clearance between 0 and 24 hours; CLperitoneal 6–24, peritoneal clearance from 6 to 24 hours; CLnondial, nondialysate clearance.

  • a Wilcoxon Mann–Whitney test.