Table 4.

Changes in endothelial cell function, arterial stiffness, and BP among those with and without resolution of intradialytic hypertension

BaselineStudy EndMean Change from Baseline to Study EndP Value
Resolution of intradialytic hypertension (n=15)
 endothelial-dependent FMD (%)1.00 (±0.78)1.37 (±0.91)0.55 (±0.96)0.05
 endothelial progenitor cell markers
  ALDHbr (% of mononuclear cells)0.026 (0.013, 0.093)0.027 (0.012, 0.051)0.001 (−0.048, 0.016)0.6
  CD34+CD133+ (% of mononuclear cells)0.033 (0.016, 0.076)0.042 (0.016, 0.049)0.001 (−0.014, 0.012)0.9
 ET-1 (pg/ml)
  prehemodialysis4.76 (±1.52)5.20 (±1.67)0.36 (±2.02)0.5
  posthemodialysis5.79 (±2.94)4.87 (±2.34)−1.02 (±3.40)0.3
  Δ hemodialysis1.04 (±2.83)−0.34 (±1.90)−1.38 (±4.45)0.3
 asymmetric dimethylarginine (µmol/L)0.70 (±0.19)0.63 (±0.19)−0.08 (±0.15)0.07
 pulse wave velocity (m/s)12.4 (±3.5)11.8 (±3.0)−0.6 (±2.2)0.3
 ambulatory BP (mmHg)
  systolic159.3 (±13.8)152.4 (±15.4)−6.9 (±20.0)0.2
  diastolic84.1 (±9.8)78.4 (±7.7)−5.0 (±9.6)0.07
 target dry weight81.5 (±21.7)81.3 (±22.9)−0.1 (±3.9)0.9
Persistent intradialytic hypertension (n=10)
 endothelial-dependent FMD (%)1.06 (±0.58)1.43 (±0.77)0.37 (±0.94)0.2
 endothelial progenitor cell markers
  ALDHbr (% of mononuclear cells)0.045 (0.031, 0.058)0.031 (0.016, 0.045)−0.006 (−0.029, −0.001)0.5
  CD34+CD133+ (% of mononuclear cells)0.035 (0.019, 0.05)0.025 (0.019, 0.049)−0.006 (−0.034, −0.022)0.8
 ET-1 (pg/ml)
  prehemodialysis5.26 (±2.57)6.19 (±3.06)0.09 (±1.46)0.8
  posthemodialysis6.22 (±3.09)6.96 (±3.50)0.42 (±1.28)0.4
  Δ hemodialysis0.96 (±1.57)0.77 (±2.17)−0.33 (±2.23)0.7
 ADMA (µmol/L)0.65 (±0.15)0.70 (±0.14)0.03 (±0.10)0.4
 PWV (m/s)10.7 (±2.20)11.3 (±3.55)0.1 (±1.9)0.8
 ambulatory BP (mmHg)
  systolic149.5 (±13.3)141.1 (±15.6)−8.4 (±11.7)0.05
  diastolic79.8 (±12.3)76.7 (±12.4)−3.1 (±4.0)0.04
 target dry weight82.1 (±18.2)81.9 (±18.3)−0.2 (±0.9)0.5
  • Values are reported as mean ± SD or medians and 25th to 75th interquartile ranges. Vasodilation units are the percentage of dilation and endothelial progenitor cells are the percentage of mononuclear cells. P values determined from paired t tests or nonparametric signed rank. FMD was normalized for peak shear rate and calculated as (FMD/peak shear rate) × 100 (21). Two PWV measurements were unable to be performed for technical reasons, two patients had inadequate samples for ET-1, and four patients had inadequate samples for ADMA. FMD, flow-mediated vasodilation; ALDHbr, aldehyde dehydrogenase activity; ET-1, endothelin-1; ADMA, asymmetric dimethylarginine; PWV, pulse wave velocity.