Pharmacokinetic Parameter | Definition | Equation or Method of Calculation |
---|---|---|

F | Fraction of ip dose absorbed | F = (Total dose − Amount of drug remaining in dialysate at the end of antibiotic dwell)/Total dose |

k_{el} | Plasma elimination rate constant | Negative slope of the log-transformed concentration versus time data obtained from plasma samples between 6 and 24 hours |

t_{1/2, el} | Plasma elimination half-life | t_{1/2, el}=ln2/k_{el} |

k_{pc 0–6} | Rate constant for distribution of drug from the peritoneal cavity between 0 and 6 hours | Negative slope of the log-transformed concentration versus time data obtained from peritoneal dialysate samples between 0 and 6 hours |

t_{1/2, pc 0–6} | Distribution half-life in the peritoneal cavity between 0 and 6 hours | t_{1/2, pc 0–6}=ln2/k_{pc 0–6} |

t_{1/2, eq} | Equilibration half-life | t_{1/2, eq}=ln2/(k_{el}+k_{pc 0–6}) |

CL_{total} | Total clearance from the systemic circulation | CL_{total} = (F × Dose)/AUC_{plasma 0–∞} |

AUC_{plasma 0–∞} | Area under the plasma concentration time curve between time 0 and infinity | Linear trapezoidal rule between 0 and 24 hours; then, extrapolation from 24 hours to infinity was calculated assuming log-linear decline |

AUC_{0–24} | Area under the concentration time curve between 0 and 24 hours | Linear trapezoidal rule between 0 and 24 hours |

Vd | Volume of distribution | Vd=CL_{plasma 0–24}/k_{el} |

CL_{plasma 0–24} | Plasma clearance between 0 and 24 hours | CL_{plasma 0-24} = (F × Dose)/AUC_{plasma 0–24} |

CL_{peritoneal 6–24} | Peritoneal clearance from 6 to 24 hours | |

CL_{nondial} | Nondialysate clearance | CL_{nondial}=(CL_{plasma 0–24})−(CL_{peritoneal 6–24}) |

ip, intraperitoneal.