Table 4.

Association of cardiac concentricity with rapid declinea in eGFRcr and eGFRcys among MESA participants with baseline eGFRcr ≥60 ml/min per 1.73 m2 by logistic regression

PredictorsnParticipants With Rapid Decline (n)Demographic Adjusted ORbFully Adjusted ORc
eGFRcr
 concentricity
  continuous (per SD=0.24)386610371.17 (1.08, 1.26)1.13 (1.04, 1.22)
  quartile (g/ml)
   1 (<0.95 for women, <1.06 for men)9662081.00 (Reference)1.00 (Reference)
   2 (0.95–1.06 for women, 1.06–1.17 for men)9672421.15 (0.92, 1.43)1.09 (0.87, 1.36)
   3 (1.07–1.20 for women, 1.18–1.35 for men)9672731.25 (1.01, 1.56)1.18 (0.95, 1.48)
   4 (≥1.20 for women, ≥1.35 for men)9663141.43 (1.15, 1.79)1.27 (1.01, 1.60)
eGFRcys
 concentricity
  continuous (per SD=0.24)38668671.16 (1.06, 1.26)1.08 (0.98, 1.17)
  quartile (g/ml)
   1 (<0.95 for women, <1.06 for men)9661741.00 (Reference)1.00 (Reference)
   2 (0.95–1.06 for women, 1.06–1.17 for men)9672141.34 (1.06, 1.69)1.27 (1.00, 1.61)
   3 (1.07–1.20 for women, 1.18–1.35 for men)9672191.27 (1.01, 1.61)1.13 (0.89, 1.44)
   4 (≥1.20 for women, ≥1.35 for men)9662601.48 (1.16, 1.87)1.22 (0.96, 1.56)
  • Values in parentheses are 95% confidence intervals. eGFRcr, estimated GFR by creatinine; eGFRcys, estimated GFR by cystatin C; MESA, Multi-Ethnic Study of Atherosclerosis; OR, odds ratio.

  • a Rapid decline defined as >5% per year.

  • b Demographic adjusted for age, race, education, baseline estimated GFR (creatinine for creatinine models; cystatin C for cystatin C models).

  • c Fully adjusted for the above variables plus body mass index, systolic BP, hypertension medications, diabetes, HDL, IL-6, and C-reactive protein.