Table 2.

Association of concentricity with decline in eGFRcr and eGFRcys among MESA participants with baseline eGFRcr ≥60 ml/min per 1.73 m2 by linear mixed models

PredictorsnDemographic Adjusted Change in eGFRaFully Adjusted Change in eGFRb
eGFRcr
 concentricity
  continuous (per SD=0.24)3866−0.18 (−0.24, −0.12)−0.14 (−0.20, −0.08)
  quartile (g/ml)
   1 (<0.95 for women, <1.06 for men)966ReferenceReference
   2 (0.95–1.06 for women, 1.06–1.17 for men)967−0.15 (−0.30, 0.01)−0.11 (−0.26, 0.04)
   3 (1.07–1.20 for women, 1.18–1.35 for men)967−0.12 (−0.27, 0.03)−0.08 (−0.23, 0.08)
   4 (≥1.20 for women, ≥1.35 for men)966−0.44 (−0.60, −0.28)−0.32 (−0.49, −0.15)
eGFRcys
 concentricity
  continuous (per SD=0.24)3866−0.13 (−0.21, −0.05)−0.09 (−0.18, −0.003)
  quartile (g/ml)
   1 (<0.95 for women, <1.06 for men)966ReferenceReference
   2 (0.95–1.06 for women, 1.06–1.17 for men)967−0.14 (−0.35, 0.07)−0.08 (−0.30, 0.14)
   3 (1.07–1.20 for women, 1.18–1.35 for men)967−0.03 (−0.25, 0.18)0.03 (−0.19, 0.25)
   4 (≥1.20 for women, ≥1.35 for men)966−0.28 (−0.51, −0.05)−0.16 (−0.41, 0.08)
  • Values in parentheses are 95% confidence intervals. eGFRcr, estimated GFR by creatinine; eGFRcys, estimated GFR by cystatin C; MESA, Multi-Ethnic Study of Atherosclerosis; eGFR, estimated GFR.

  • a Demographic adjusted: adjusted for age, race, and education level.

  • b Fully adjusted for above variables plus body mass index, systolic BP, hypertension medications, diabetes, HDL, IL-6, and C-reactive protein.